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What really drives the way we eat? In this episode of The Curious Advantage Podcast, Paul Ashcroft, Simon Brown, and Garrick Jones are joined by Dr. Giles Yeo—geneticist, author, and professor at the University of Cambridge to explore the science behind appetite, genetics, and weight loss. Dr. Giles Yeo explains how our eating behaviours are more biological than we think, shaped by the brain’s role in decision-making and our unique genetic makeup. He unpacks the truth behind obesity and reveals why weight management is far more complex than just calorie counting. The conversation dives into the impact of ultra-processed foods, food environments, and weight loss drugs like Ozempic and Mounjaro, along with what happens when people stop taking them. They also explore the idea of a red, amber and green food labelling system to help guide healthier choices. Together, they examine how curiosity, empathy and a deeper understanding of human biology can challenge diet myths and shape more supportive approaches to wellness. Why Calories Don't Count: How We Got the Science of Weight Loss Wrong  available on Amazon: https://www.amazon.co.uk/Why-Calories-Dont-Count-Science/dp/B08LZPDT4W/?_encoding=UTF8&pd_rd_w=Dv6kL&content-id=amzn1.sym.6b6d4bc1-013f-4684-8a3d-174e5cf88d17&pf_rd_p=6b6d4bc1-013f-4684-8a3d-174e5cf88d17&pf_rd_r=262-0311421-9608643&pd_rd_wg=R2KmB&pd_rd_r=4da738c0-df01-4abe-9167-ab9a06df2b89&ref_=aufs_ap_sc_dsk 00:00 Introduction to Genetics and Dr. Giles Yeoh 01:13 Giles Yeoh's Journey in Genetics 04:15 Understanding Eating Behaviors 11:00 The Role of DNA in Eating Responses 14:19 Appetite and the Brain's Influence 18:58 Implications for Weight Management 24:24 The Impact of Ultra-Processed Foods 25:46 Understanding Ultra-Processed Foods 28:42 The Complexity of Calories 30:18 Rethinking Food Quality and Nutrition Labels 33:41 The Role of Dietary Choices 40:38 Weight Loss Medications: Mechanisms and Implications 52:30 The Social Perspective on Obesity About The Curious Advantage Podcast Join the authors of The Curious Advantage in an exploration of how individuals and organizations can harness the power of curiosity to drive success in our new digital reality. In each episode, they engage in enlightening conversations with world-leading experts from a diversity of disciplines to bring to life the latest understanding of curiosity in a way that’s useful to anyone looking to embark on a journey of discovery, navigate challenges, and unlock opportunities. About The Curious Advantage Book The Curious Advantage is an exploration of the idea of Curiosity and its increasing importance for thriving in the digital age. Taking the widest possible exploration of things Curious – historical, contemporary, neuro-scientific, anthropological, behavioural, semantic and business-focused. At the heart of the book is our model of Curiosity, called ’Sailing the 7C’s of Curiosity’. This model provides individuals with a practical framework for how to be successfully Curious and use Curiosity as a power skill to unlock their own potential. To find out more visit: (http://curiousadvantage.com/) curiousadvantage.com (http://curiousadvantage.com) Get your copy of The Curious Advantage on Amazon (https://www.amazon.co.uk/Curious-Advantage-Paul-Ashcroft-ebook/dp/B08931WBT9/) The Curious Advantage Audiobook is also available on Audible (https://www.audible.co.uk/pd/The-Curious-Advantage-Audiobook/B0B916YKSY?qid=1660223133&sr=1-2&ref=a_search_c3_lProduct_1_2&pf_rd_p=c6e316b8-14da-418d-8f91-b3cad83c5183&pf_rd_r=Q2QA788N5EEKV73BGPNG) Follow The Curious Advantage on LinkedIn (https://www.linkedin.com/company/65416363/admin/feed/posts/) and Instagram (https://www.instagram.com/curiousadvantage/) The Curious Advantage Podcast is executive produced by Jessica Wickham and Aliki Paolinelis. Audio editing is done by Danny Cross and video editing by Jessica Wickham. 

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Does metformin cause weight loss Metformin an oral type diabetes medicine may lead to a modest weight loss and does not usually lead to significant if any weight gain In various clinical studies when metformin was used alone it led to a weight loss of to kg to lbs in patients Many clinicians consider metformin a weight neutral treatment meaning it does not cause a significant amount of weight gain or lossMetformin brand name Fortamet Glumetza is approved by the FDA to be used with diet and exercise to improve glycemic blood sugar control in adults and pediatric patients years of age and older with type diabetes mellitus It is classified as a biguanide and has been approved by the FDA since Most studies have not seen a significant amount of weight loss with metformin when used alone and it does not meet the weight loss levels seen in studies for Ozempic Wegovy or Mounjaro It also does not cause weight gain like insulin or a sulfonylurea treatment for example glimepiride glipizide glyburideMetformin is usually the first drug used to treat patients with type diabetes Metformin is favored over many other diabetes drugs as initial treatment because of its ability to control blood sugar levels lack of weight gain and low blood sugar oral formulation and generic affordabilityOverall the best way to lose weight while taking metformin is to adhere to a recommended diet and exercise program It can also be used in combination with other type diabetes medications includinginsulinoral sulfonylureas eg glipizide glyburide glimepirideglucagonlike peptide GLP receptor agonistssodiumglucose cotransporter SGLT inhibitorsdipeptidyl peptidase DPP inhibitorsrepaglinidepioglitazoneStaying at a healthy weight is an important part of controlling type diabetes If you are concerned about gaining weight with your medicine speak to your healthcare provider about drug and nondrug treatments that may help promote weight loss as well as control your blood sugar Today many treatments are available that not only effectively control blood sugar but can also help with significant weight loss in type diabetesRelated How do Mounjaro Wegovy Ozempic compare for weight lossWeight loss with metformin in adultsNumerous studies looking at the use of metformin for the treatment of type diabetes have reported modest weight loss when used in addition to diet and exerciseStudy Metformin vs placeboIn one study conducted by the manufacturer metformin dose up to mgday was compared to a placebo treatment an inactive agent in a study lasting weeksThe average weight of people at the start of the study was kg lbs kg in those taking only metformin and kg in the placebo groupAfter weeks people in the metformin group lost an average of kg lbs vs kg lbs in the placebo groupStudy Metformin vs glyburideAnother study done by the manufacturer evaluated weight loss between metformin metformin combined with glyburide an oral sulfonylurea for type diabetes and glyburide used aloneIn the group receiving metformin alone the average body weight at the start of the study was kg lbs By the th week patients in this group had lost an average of kg lbsIn the group taking metformin combined with glyburide the average weight at the start of the study was kg lbs and they gained an average of kg lbs at weeksIn those taking glyburide alone who weighed an average of kg lbs at baseline a weight loss of kg lb was seenStudy Metformin vs rosiglitazone or glyburideIn a study with over obese patients recently diagnosed with type diabetes patients were given either rosiglitazone a thiazolidinedione agent used to treat type diabetes metformin or glyburide a sulfonylurea as initial treatmentBody weights were assessed over a year period In the metformin group the mean weight decreased by kg lbs More frequent gastrointestinal stomach side effects occurred in this group compared to the othersIn the rosiglitazone group the average weight increased by kg lbs and was associated with greater edema fluid retention and LDL bad cholesterol elevationsIn the glyburide group patients gained kg lbs over the first year but weight stabilized thereafter Higher rates of low blood sugar hypoglycemia were seen in the glyburide group vs other treatmentsStudy Metformin vs dulaglutide a GLP agonistIn a trial comparing metformin with dulaglutide a glucagonlike peptide GLP receptor agonist weight loss at and weeks was similar to the dulaglutide mg dose but smaller with the dulaglutide mg dosemetformin loss of kg lbsdulaglutide mg loss of kg lbsdulaglutide mg loss of

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