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Ozempic and other GLP-1 drugs are changing the game in weight loss and diabetes treatment—but what are the risks, side effects, and long-term impacts? Experts weigh in on everything you need to know. 💉🔥 #Ozempic #GLP1 #WeightLoss #DiabetesTreatment #HealthNews #OzempicSideEffects #MetabolicHealth #FitnessTrends #GLP1Drugs

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In this episode, my guest is Dr. Zachary Knight, Ph.D., a professor of physiology at the University of California, San Francisco (UCSF), and Howard Hughes Medical Institute (HHMI) investigator. We discuss how the brain controls our sense of hunger, satiety, and thirst. He explains how dopamine levels impact our cravings and eating behavior (amount, food choices, etc) and how we develop and can change our food preferences and adjust how much we need to eat to feel satisfied.   We discuss factors that have led to the recent rise in obesity, such as interactions between our genes and the environment and the role of processed foods and food combinations. We also discuss the new class of medications developed for the treatment of obesity and diabetes, including the GLP-1 agonists semaglutide (Ozempic, Wegovy) and tirzepatide (Mounjaro). We discuss how these medications work to promote weight loss, the source of their side effects, and the newer compounds soon to overcome some of those side effects, such as muscle loss.   Dr. Knight provides an exceptionally clear explanation for our sense of hunger, thirst, and food cravings that translates to practical knowledge to help listeners better understand their relationship to food, food choices, and meal size to improve their diet and overall health. Access the full show notes, including referenced articles, books, people mentioned, and additional resources: https://www.hubermanlab.com/episode/dr-zachary-knight-the-science-of-hunger-medications-to-combat-obesity Thank you to our sponsors AG1: https://drinkag1.com/huberman BetterHelp: https://betterhelp.com/huberman Eight Sleep: https://eightsleep.com/huberman Waking Up: https://wakingup.com/huberman LMNT: https://drinklmnt.com/huberman Huberman Lab Social & Website Instagram: https://www.instagram.com/hubermanlab Threads: https://www.threads.net/@hubermanlab Twitter: https://twitter.com/hubermanlab Facebook: https://www.facebook.com/hubermanlab TikTok: https://www.tiktok.com/@hubermanlab LinkedIn: https://www.linkedin.com/in/andrew-huberman Website: https://www.hubermanlab.com Newsletter: https://www.hubermanlab.com/newsletter Dr. Zachary Knight UCSF academic profile: https://profiles.ucsf.edu/zachary.knight HHMI profile: https://www.hhmi.org/scientists/zachary-knight Publications: https://knightlab.ucsf.edu/publications Lab website: https://knightlab.ucsf.edu X: https://x.com/zaknight Instagram: https://www.instagram.com/zknightsf LinkedIn: https://www.linkedin.com/in/zachary-knight-29a37977 Timestamps 00:00:00 Dr. Zachary Knight 00:02:38 Sponsors: BetterHelp, Helix Sleep & Waking Up 00:07:07 Hunger & Timescales 00:11:28 Body Fat, Leptin, Hunger 00:17:51 Leptin Resistance & Obesity 00:20:52 Hunger, Food Foraging & Feeding Behaviors, AgRP Neurons 00:30:26 Sponsor: AG1 00:32:15 Body Weight & Obesity, Genes & POMC Neurons 00:39:54 Obesity, Genetics & Environmental Factors 00:46:05 Whole Foods, Ultra-Processed Foods & Palatability 00:49:32 Increasing Whole Food Consumption, Sensory Specific Satiety & Learning 00:58:55 Calories vs. Macronutrients, Protein & Salt 01:02:23 Sponsor: LMNT 01:03:58 Challenges of Weight Loss: Hunger & Energy Expenditure 01:09:50 GLP-1 Drug Development, Semaglutide, Ozempic, Wegovy 01:19:03 GLP-1 Drugs: Muscle Loss, Appetite Reduction, Nausea 01:23:24 Pharmacologic & Physiologic Effects; GLP-1 Drugs, Additional Positive Effects 01:30:14 GLP-1-Plus Development, Tirzepatide, Mounjaro, AMG 133 01:34:49 Alpha-MSH & Pharmacology 01:40:41 Dopamine, Eating & Context 01:46:01 Dopamine & Learning, Water Content & Food 01:53:23 Salt, Water & Thirst 02:03:27 Hunger vs. Thirst 02:05:46 Dieting, Nutrition & Mindset 02:09:39 Tools: Improving Diet & Limiting Food Intake 02:14:15 Anti-Obesity Drug Development 02:17:03 Zero-Cost Support, Spotify & Apple Follow & Reviews, YouTube Feedback, Social Media, Neural Network Newsletter #HubermanLab #Health #Obesity Title Card Photo Credit: Mike Blabac - https://www.blabacphoto.com Disclaimer: https://www.hubermanlab.com/disclaimer

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The first week of taking Semaglutide for weight loss can be an exciting and transformative time for individuals looking to improve their health and well-being. While everyone’s experience may vary, there are some common expectations and challenges that many people face during this initial period. In this article, we will explore what you can expect during the first week of Semaglutide weight loss, including the potential side effects, benefits, and tips for success.

Initial Adjustment Period:

During the first week of taking Semaglutide, you may experience some initial side effects as your body adjusts to the medication. Common side effects include nausea, vomiting, diarrhea, and decreased appetite. These symptoms are usually mild and tend to improve over time as your body becomes more accustomed to the medication. It is essential to stay hydrated and listen to your body during this adjustment period.

Additionally, you may notice an increase in energy levels and a decrease in hunger cravings during the first week of taking Semaglutide. This can help you make healthier food choices and stick to your weight loss plan more effectively. However, it is essential to remember that Semaglutide is not a magic pill and should be combined with a healthy diet and regular exercise for optimal results.

Some individuals may also experience changes in their taste preferences during the first week of taking Semaglutide. This can be attributed to the medication’s effects on appetite regulation and food cravings. You may find that you are more inclined to choose healthier options and avoid high-calorie, processed foods. Embracing these changes can help you establish long-term healthy eating habits.

Monitoring Your Progress:

It is crucial to monitor your progress during the first week of taking Semaglutide to track your weight loss journey effectively. Keep a journal of your daily food intake, exercise routine, and any side effects you may experience. This can help you identify patterns and make adjustments as needed to optimize your results. Additionally, regular weigh-ins and body measurements can provide tangible evidence of your progress and keep you motivated along the way.

During the first week, you may also notice changes in your body composition, such as a decrease in bloating or water retention. This can contribute to the initial weight loss that many people experience when starting Semaglutide. While rapid weight loss is common in the beginning, it is essential to focus on long-term health and sustainability. Set realistic goals and celebrate small victories to stay motivated on your journey.

As you progress through the first week of taking Semaglutide, you may start to notice improvements in your overall well-being, such as increased energy, better sleep quality, and improved mood. These positive changes can have a significant impact on your motivation and commitment to your weight loss goals. Embrace these improvements and use them as fuel to continue making healthy choices moving forward.

Seeking Support and Guidance:

Throughout the first week of taking Semaglutide, it is essential to seek support and guidance from healthcare professionals, friends, and family members. Discuss any concerns or questions you may have with your doctor or a registered dietitian to ensure you are on the right track. Surround yourself with a supportive network that can encourage and motivate you on your weight loss journey.

Joining a support group or online community of individuals taking Semaglutide for weight loss can also provide valuable insights and motivation. Sharing your experiences, challenges, and successes with others who are on a similar journey can help you stay accountable and inspired. Remember that you are not alone in your weight loss efforts, and seeking support can make a significant difference in your success.

As you navigate the first week of taking Semaglutide for weight loss, it is essential to approach the experience with patience, positivity, and an open mind. Embrace the changes happening within your body and celebrate the progress you make, no matter how small it may seem. By setting realistic goals, staying consistent with your healthy habits, and seeking support when needed, you can set yourself up for long-term success with Semaglutide weight loss.

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I've been considering starting a weight loss treatment for a while now. After researching various options available in the UK and watching several informative videos, I've decided to go with Mounjaro. This licensed medication is designed to help treat obesity in the UK, and I’ll be paying for it privately. I'm optimistic that it will enhance my overall health over time. I would truly appreciate your support on this journey and hope for understanding rather than judgment. I plan to share weekly videos documenting my progress in a separate playlist. Please remember to be kind in your comments; any disrespectful remarks will be removed. If you have any questions, feel free to ask in the comments below! #mounjaro #tirzepatide #mounjarojourney #mounjarouk

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Hey ya'll! In this weeks episode I wanted to share with you guys this cool new supplement that was made SPECIFICALLY for those of us on a GLP-1 medication. Replenza is nutritional support for us and has so many benefits to help fill in he gaps for things we need like muscle recovery, electrolytes, collagen, vitamins and more! Check them out in this link below. https://www.replenzalabs.com/pages/lifestyle-guide In this video I'm also sharing how to make a quick and easy smoothie bowl, come to work with me in NYC and do some shopping in H&M :-) If you are enjoying the vlogs please show some love in the comments and don't forget to like this video too! xoxoxoxox Timestamps: Smoothie Bowl - 2:30 Replenza Unboxing - 6:00 Shopping: 19:50 GLP-1 Update: 22:35 Mochi Health Link: https://app.joinmochi.com/eligibility?utm_source=influencers&ptcode=leaqqv Code: LEAQQV Keep up with me on socials: Instagram: Keishaapproved Tiktok: Keishaapproved #weightloss #looseweight #glp1 #mounjaro #mounjarojourney #tirzepatide #ozempic #wegovy #weightlossjourney #weightloss #vlogger #updates #weightlosstransformation #milenial @ReplenzaLabs

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#mounjaro #Weightloss #Tirzepatide #zepbound I'm back with another update. Its been a really busy time for me, but I am back to let y'all know how things have been going... Like, Comment & Subscribe... Thank you! My other channel (with my wife): @YoKendog ---------------------- FOLLOW ME: Instagram: 2BeFatNoMore MyFitnessPal: Eat2LiveInOKC _______________________ I am paying full price, out of pocket, for Mounjaro. If you would like to help me continue my journey: Venmo - https://www.venmo.com/u/KEDOGN PayPal - [email protected] Cash App - $Kedogn Any and all donations are very appreciated. _______________________ This is my story... I have struggled with weight issues for most of my life. I'd lose some, then gain it and more back every time. I have tried it all: fasting, Weight Watchers, NutriSystem, Herbalife, Slimfast, Adkins, South Beach... you name a fad diet in the past 30 years and I have probably tried it and FAILED! In late December 2021 my wife and I moved to Oklahoma City for work. I looked at this as a 'fresh new start' and I decided that I was going to start a new diet/lifestyle just after the first of the year and so on January 10, 2022, I made the change I needed to and that lasted about a month. I struggled HARD to lose weight. In April of that year I hurt my right knee really bad and had to see a specialist about that. He gave me this look after checking out my knee, and then he looked away towards the wall. He did this a couple times until *I* finally said to him, "Doc are you telling me I need to lose weight?" and he replied something fancy that essentially meant "YES!!". That started me right there on a journey. I **HAD** to lose weight. He was the FIRST ever doc to tell me that, so this would be my motivation... however, a stop by Taco Bell on the way home first was needed since I would be 'going without'. Over the next 4 months I lost and maintained a loss of just 35lbs when I finally set up an appointment with my new Primary Care Physician. I dreaded that appointment as I just knew that she would want to talk about weight and sure enough, about 15 minutes into it she asked me about my weight and if I was interested in losing it. I told her "it's not like I enjoy having it, Doc". She then mentioned Mounjaro to me and I fought her on it immediately. I told her I didn't want to inject into my body something that wasn't meant for it, being that Mounjaro was a medicine for those with Type 2 Diabetes, and I didn't have that. She understood and eventually talked me into trying it. I gave in, reluctantly, and I agreed to 3 months. I told her that if it didn't work in 3 months, I don't want to hear anything else from her again about my weight. That I would give it my best for those 3 months and if it fails, it fails and nothing else can be said. I took my first Mounjaro shot around 9:15am on September 2, 2022 and I weighed 560lbs at that time. Videos on this channel detail my journey from then until now as I have lost over 263lbs since that first shot, even though I have not been able to take the medication as prescribed for various reasons, one being cost. This medicine really is life changing and these videos are the story of how Mounjaro changed my life for the better....#mounjaro ..

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