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Dr Tamaan K. Osbourne-Roberts reviews the list of patients who probably should not be taking GLP-1 receptor agonists. https://www.medscape.com/viewarticle/glp-1-ras-when-not-prescribe-2024a1000nd8?src=soc_yt -- TRANSCRIPT -- Hi. I'm Tamaan K. Osbourne-Roberts, family medicine physician and lifestyle medicine physician, here to discuss GLP-1 receptor agonist (RA) contraindications — the skinny on when not to prescribe. It can be hard not to think of GLP-1 RAs like Ozempic and Mounjaro as silver bullets, long-awaited miracle drugs that we should probably be putting in the water. And it's true they have the potential to help a lot of people. However, there are definitely groups of patients who should not take these drugs or should take them with caution. They include the following: Patients with a family history of certain cancers. Given that GLP-1 RAs can increase the risk for thyroid cancer, patients with a personal or family history of medullary thyroid cancer or multiple endocrine neoplasia type 2 should not take these drugs. Gut motility issues. Since one of the primary mechanisms of action for these drugs is to slow down the gut, patients with gastroparesis — diabetic or otherwise — or other gut motility issues should avoid these drugs. Patients with inflammatory bowel disease also should not use GLP-1 RAs. Pancreatitis. These medications can increase the risk for serious pancreatitis on their own, so use in patients who have had pancreatitis already is not recommended. Renal impairment. An eGFR [estimated glomerular filtrationrate] below threshold, typically around 30 mL/min/1.73 m2, excludes GLP-1 RAs for some patients. Be certain to check the threshold for individual medications before prescribing. And finally, pregnancy. These drugs generally should not be used in pregnancy, and people of childbearing age with the ability to become pregnant should use contraception while taking these medications. GLP-1 RAs are great medications and have the potential to revolutionize obesity medicine, but like all drugs, it's important to use them safely. Knowing when not to prescribe them is an important step in ensuring patient safety and will help ensure they are available for those who need them. Transcript in its entirety can be found by clicking here: https://www.medscape.com/viewarticle/glp-1-ras-when-not-prescribe-2024a1000nd8?src=soc_yt

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Obesity has become a major health concern worldwide, with millions of people struggling to lose weight and improve their overall well-being. In recent years, there has been a growing interest in medications that can aid in weight loss, including semaglutide. Semaglutide is a medication that was originally developed to treat type 2 diabetes, but its weight loss benefits have also been recognized. In this article, we will explore the scientific evidence and user testimonials regarding the effectiveness of semaglutide for weight loss.

Semaglutide: A Potential Solution for Weight Loss

Semaglutide belongs to a class of medications known as glucagon-like peptide-1 receptor agonists (GLP-1 RAs), which work by mimicking the effects of a hormone called GLP-1. GLP-1 is released in response to food intake and helps regulate blood sugar levels, decrease appetite, and promote weight loss. By activating GLP-1 receptors in the brain, semaglutide can help individuals feel full sooner and eat less, leading to a reduction in body weight.

In clinical studies, semaglutide has demonstrated promising results as a weight loss medication. One of the most notable trials, called the STEP 1 study, involved over 1,900 participants with obesity or overweight. The participants were randomly assigned to receive either semaglutide or a placebo for 68 weeks. Those who took semaglutide lost an average of 14.9% of their body weight, compared to 2.4% in the placebo group. This significant difference highlights the potential of semaglutide as an effective option for weight management.

Another important trial, known as the STEP 4 study, focused on the long-term effects of semaglutide on weight loss. In this study, participants who had previously completed the STEP 1 trial were given the option to continue taking semaglutide for an additional 48 weeks. The results showed that those who continued with semaglutide experienced sustained weight loss, with an average total weight loss of 17.4% after 116 weeks. This sustained weight loss is essential for preventing weight regain and maintaining long-term success.

User Testimonials: Real-life Experiences with Semaglutide

While clinical studies provide valuable insights into the effectiveness of semaglutide for weight loss, user testimonials offer a glimpse into real-life experiences with the medication. Many individuals who have tried semaglutide report significant improvements in their weight, overall health, and quality of life. Some users describe feeling more in control of their eating habits, experiencing less cravings for unhealthy foods, and having increased energy levels.

One testimonial comes from Sarah, a 45-year-old woman who had struggled with obesity for years. After starting semaglutide as part of a clinical trial, Sarah was amazed by the results. She lost over 30 pounds in six months, felt more confident and energetic, and was able to engage in activities that she had previously avoided due to her weight. Sarah credits semaglutide for helping her achieve a healthier lifestyle and hopes to inspire others to consider this option.

Another user, John, shared his journey with semaglutide on social media, where he documented his weight loss progress and milestones. John, who had tried various diets and exercise regimens without success, found that semaglutide was the missing piece in his weight loss journey. He lost over 50 pounds in a year, transformed his body composition, and improved his overall well-being. John’s story serves as a reminder that semaglutide can be a game-changer for individuals struggling with obesity.

Overall, the combination of scientific evidence from clinical studies and positive feedback from users suggests that semaglutide is a promising option for weight loss. However, it is essential to consult with a healthcare provider before starting any new medication and to discuss the potential benefits and risks of semaglutide. With proper guidance and support, individuals who are looking to lose weight and improve their health may find semaglutide to be a valuable tool in their journey towards a healthier lifestyle.

Conclusion: Is Semaglutide the Future of Weight Loss?

In conclusion, semaglutide has shown significant potential as a weight loss medication, with clinical studies demonstrating its effectiveness in reducing body weight and promoting long-term weight management. User testimonials further support the positive impact of semaglutide on individuals’ weight loss journeys, highlighting its ability to help people achieve their health goals and improve their quality of life. While more research is needed to fully understand the mechanisms of action and long-term effects of semaglutide, the current evidence suggests that this medication could be a game-changer in the field of weight loss interventions. As always, it is essential to work closely with healthcare providers to determine the best treatment options for individual needs and goals. With the right support and guidance, semaglutide could indeed be the future of weight loss for many individuals struggling to achieve a healthier weight and lifestyle.

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In this episode of The Downsized, Laraine and Christopher Durham delve into their personal journeys with GLP-1 medications for the treatment of the disease of obesity, providing a candid discussion on what to expect. The couple shares their successes, challenges, and the real pace of weight loss while using GLP-1s such as compounded tirzepatide, Mounjaro, and Zepbound. Christopher has lost 94 pounds and Laraine 52 pounds through dedicated use of these medications, and they discuss weekly weight trends, dosages, and side effects. They stress the importance of managing expectations, following medical advice, and understanding that sustainable weight loss is a marathon, not a sprint. The episode also covers the community aspect of their YouTube channel, with weekly weigh-ins, interviews, and live streams aimed at educating and supporting others on a similar journey. Emphasizing the significance of proper nutrition, tracking progress, and staying patient, the Durhams offer a comprehensive look at the realities of weight loss through GLP-1 medications. BOOK THE DOWNSIZED AT SEA CRUISE: https://thedownsized.org/downsized-at-sea-2025/ DOWNSIZED WEBSITE: https://thedownsized.org/ JOIN CLUB DOWNSIZED: https://www.youtube.com/@thedownsized/join DOWNSIZED GLP-1 COMPANION PRODUCT STORE: https://thedownsized.org/downsized-store We use Mochi Health: https://joinmochi.com/. Use Laraine’s code for $40 off: QIYGO8. 00:00 Introduction to GLP-1 Weight Loss 00:22 Meet Laraine and Christopher 02:04 Our Weight Loss Journey Begins 03:33 Discovering Mounjaro and Telehealth 06:39 Starting the Medication: Expectations and Results 08:57 Understanding GLP-1 Medications 10:45 Tracking Progress and Results 15:55 Christopher's Weight Loss Experience 21:22 Understanding Weight Management with Medication 21:59 The Math Behind Weight Loss 22:11 Personal Weight Loss Journey 23:39 Managing Plateaus and Body Responses 25:06 Importance of Consistency and Habits 25:56 Tracking and Nutrition Insights 32:26 Adjusting Medication and Side Effects 40:25 Encouragement and Community Support 41:28 Join the Conversation and Stay Connected

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With the rise of the keto diet trend, more and more people are looking for ways to support their weight loss and health goals. One popular method that has emerged in recent years is the use of keto pills, supplements that claim to help users enter and maintain a state of ketosis more easily. These pills have gained popularity for their convenience and potential benefits, leading to a surge in demand both online and in stores.

Amazon Meets Shark Tank

As the popularity of keto pills continues to grow, online marketplaces such as Amazon have become key players in the industry. With the rise of e-commerce, more consumers are turning to online platforms to purchase their favorite products, including keto pills. This shift has created new opportunities for both established brands and up-and-coming companies to reach a wider audience and compete in the market.

One notable example of this trend is the intersection of Amazon and Shark Tank, two powerful forces in the world of entrepreneurship and consumer goods. Shark Tank, a popular TV show where aspiring entrepreneurs pitch their products to a panel of wealthy investors, has featured several keto pill companies in recent seasons. These companies have leveraged their appearances on the show to gain exposure and attract new customers, leading to increased sales and brand recognition.

By tapping into the reach and credibility of Amazon and the platform’s vast customer base, keto pill companies have been able to expand their businesses and connect with a wider audience. Through strategic marketing and partnership efforts, these companies have been able to leverage the online marketplace to drive sales, increase brand visibility, and grow their customer base.

The Rise of Keto Pills Online

With the increasing demand for keto pills, more and more companies are entering the market to meet consumer needs. This growing competition has fueled innovation and product development, leading to a wider variety of options for consumers to choose from. Companies are constantly seeking ways to differentiate themselves from competitors, whether through unique formulations, marketing strategies, or pricing models.

One of the key advantages of purchasing keto pills online is the convenience and accessibility it offers to consumers. With just a few clicks, customers can browse through a wide selection of products, read reviews, compare prices, and make purchases from the comfort of their own homes. This ease of shopping has played a significant role in the popularity of keto pills and the growth of the online market.

As the keto diet trend continues to gain momentum, the market for keto pills is expected to expand further in the coming years. With the support of online platforms like Amazon and the exposure from shows like Shark Tank, keto pill companies are well-positioned to capitalize on this growing trend and attract new customers. Whether you’re a seasoned keto dieter or just starting out, the rise of keto pills online offers a convenient and accessible way to support your health and wellness goals.

Summary & FAQ

In summary, the intersection of Amazon, Shark Tank, and the rise of the keto diet trend has created new opportunities for companies in the keto pill industry. With the convenience and accessibility of online platforms, consumers have more options than ever to support their health and weight loss goals with keto pills. Whether you’re looking for a unique formulation, competitive pricing, or brand recognition, the online market for keto pills offers a wide range of choices to suit your needs.

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As the market for keto pills continues to grow, consumers may have questions about the safety, effectiveness, and legitimacy of these products. Here are some frequently asked questions to help guide your decision-making process:

Q: Are keto pills safe to use for weight loss?

A: While keto pills may help support weight loss goals, it’s important to consult with a healthcare professional before starting any new supplement regimen to ensure it’s safe and appropriate for your individual needs.

Q: How do keto pills work to support ketosis?

A: Keto pills typically contain ingredients that help the body enter and maintain a state of ketosis, where it burns fat for fuel instead of carbohydrates. These ingredients may include exogenous ketones, MCT oil, and other compounds that support metabolic processes.

Q: Can I trust keto pill companies that sell products online?

A: It’s important to research and vet companies before making a purchase, including reading reviews, checking for third-party lab testing, and verifying the ingredients and claims made by the company. Look for companies with a strong reputation and track record of customer satisfaction.

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