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Some people eat too much food. Others eat unhealthy food, perhaps because they cannot afford healthy alternatives. Other people continue to eat a balanced diet but still struggle with their weight. How we eat and how our bodies react to food greatly affects our health. More than a third of all deaths today are caused by diseases such as obesity and type 2 diabetes. But why does the body tell us that it wants more food – even though it has enough energy? And can you get the body to settle for what it needs by adjusting the body’s control systems? These questions have puzzled researchers for decades. And translating new knowledge into something to combat these diseases turned out to be extremely challenging. In the 1990s, as the obesity pandemic spreads, even young people start to lose their ability to keep their body weight and blood glucose in balance. In turn, researchers and pharmaceutical companies set out to find new remedies. Follow the Episode 1 "A diabetes doctor’s dream" of this year's Advent Calendar: The Story of GLP-1. 00:00:00 Introduction: Eating Habits and Health 00:00:14 Impact of Obesity and Type 2 Diabetes 00:00:28 Understanding Body's Hunger Signals 00:01:00 Efforts to Combat Obesity in the 1990s 00:01:40 Lotter’s Journey at Novo Nordisk 00:02:00 Challenges Faced by Novo Nordisk in the 1990s 00:02:50 Lotter's Mission and New Leadership 00:03:40 Discovering GLP-1 and Its Potential 00:04:40 Jens Reifeld’s Research Journey 00:05:20 Discovery of GLP-1's Role in Diabetes 00:06:40 Early Clinical Data and Challenges with GLP-1 00:07:30 Turning GLP-1 into a Viable Drug 00:08:10 Overcoming Obstacles and Future Directions

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Welcome to our discussion on GLP-1 medication in the context of their weight loss licensing. All medication comes with risk, but as this class of medication has many benefits, including aesthetics, we believe many people have lost touch with the fact that these are regulated medication. We have became aware of online communities providing medical advice for GLP-1 medication, this is highly dangerous and this should not be a primary source of information and should be discussed with your healthcare team. There is a lot to discuss and we are aware that we cannot cover everything in this episode, also, please see our references below for any further reading. If you would like to go to a particular section, please click on the time stamp below (please note this podcast was extremely hard to time stamp, so we did our best): 00:08 - Why are we discussing GLP-1 medications again? 01:54 - Online weight-loss communities are more detrimental than good 09:58 - How is medication regulated in the UK? 16:32 - Are online pharmacies helping the situation? 20:34 - GLP-1 medication does require you to adopt a healthy lifestyle 21:58 - The controversial aspects of health? 28:52 - Social media versus health care professionals 29:58 - Let’s discuss ‘Big Pharma’ 33:08 - Our final thoughts and key points Here is our podcast link: https://open.spotify.com/show/5kJoyk0uY8u1H8CmgNDWzo?si=JF4_mY8oSES520KcOaHwhA Sign up to our newsletter: https://mailchi.mp/c15c44eee6a0/thechemistcouplepodcast As always, this podcast is for informational purposes only and should not be used in substitute to seeing a healthcare professional. Any questions, please reach out to us and thanks for listening! Here is a list of the sources that we used to make this podcast: https://www.nejm.org/doi/full/10.1056/NEJMoa2206038 https://www.nejm.org/doi/full/10.1056/NEJMoa1411892 https://www.nejm.org/doi/10.1056/NEJMoa2032183?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed Rang & Dale’s Pharmacology 10th edition - general pharmacological overview