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Become a member to watch the full episode, plus gain immediate access to our entire back catalog of AMA episodes! Subscribe now: https://bit.ly/3Hfq0kV In this “Ask Me Anything” (AMA) episode, Peter and Bob discuss all things related to GLP-1 agonists—a class of drugs that are gaining popularity for the treatment of obesity. They cover the discovery of these peptides, their physiology, and what it is they do in their natural state. Next, Peter and Bob break down a recently published study which showed remarkable results for weight loss and other metabolic parameters using a once-weekly injection of the GLP-1 agonist drug semaglutide, also known as Ozempic, in overweight and obese patients. Finally, they compare results from the semaglutide study to results from various lifestyle interventions and give their take on the potential future of GLP-1 agonists. In this sneak peek, we discuss: 00:00 - Intro 00:10 - Remarkable results of a recent study in overweight adults 02:15 - Key background on insulin, glucagon and the incretin effect to appreciate the effects of semaglutide In the full episode, we also discuss: -What is GLP-1 and how does it work? -2021 semaglutide study: remarkable results, side effects, and open questions; -Semaglutide vs. lifestyle interventions: comparing results with semaglutide vs. lifestyle interventions alone; -Closing thoughts and open questions on the therapeutic potential of semaglutide; and -More. Read the show notes for this episode here: https://bit.ly/3nbZYac -------- About: The Peter Attia Drive is a weekly, ultra-deep-dive podcast focusing on maximizing health, longevity, critical thinking…and a few other things. With over 35 million episodes downloaded, it features topics including fasting, ketosis, Alzheimer’s disease, cancer, mental health, and much more. Peter is a physician focusing on the applied science of longevity. His practice deals extensively with nutritional interventions, exercise physiology, sleep physiology, emotional and mental health, and pharmacology to increase lifespan (delay the onset of chronic disease), while simultaneously improving healthspan (quality of life). Learn more: https://bit.ly/3kBNdUG Subscribe to receive exclusive subscriber-only content: https://bit.ly/3Hfq0kV Sign up to receive Peter's email newsletter: https://bit.ly/30mqvII Connect with Peter on: Facebook: http://bit.ly/PeterAttiaMDFB Twitter: http://bit.ly/PeterAttiaMDTW Instagram: http://bit.ly/PeterAttiaMDIG Subscribe to The Drive: Apple Podcast: http://bit.ly/TheDriveApplePodcasts Overcast: http://bit.ly/TheDriveOvercast Spotify: http://bit.ly/TheDriveSpotify Google Podcasts: http://bit.ly/TheDriveGoogle

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Elon Musk Shares WEIGHT LOSS Pic, Calls Himself 'Ozempic Santa' .Elon Musk stuns fans with a new post showing off his slimmed-down figure, dressed as Santa but without the usual belly. In the image, he dubs himself "Ozempic Santa," joking about his weight loss journey. Musk shares that he tried Ozempic but switched to Munaro, a similar drug with fewer side effects. He’s not the only celebrity benefiting from weight-loss drugs, as Whoopi Goldberg and Dr. Terry Dubrow also praised their effectiveness. Musk advocates for making these treatments more accessible to improve health across the U.S. #ElonMusk #WeightLossJourney #OzempicSanta #Munaro #SlimDown #CelebrityWeightLoss #HealthTransformation #WeightLossGoals #ElonMuskTransformation #FitnessMotivation #CelebrityHealth #WeightLossDrugs #HealthAndWellness #Ozempic #Tepati #ViralTransformation

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Semaglutide, a drug traditionally used to treat type 2 diabetes, has recently gained attention for its potential as a weight loss treatment in non-diabetic individuals. This injectable medication works by mimicking the action of a hormone that regulates blood sugar levels and appetite. Studies have shown promising results in terms of weight loss, leading many to consider semaglutide as a potential solution for obesity.

How Does Semaglutide Work for Weight Loss?

Semaglutide works by binding to receptors in the brain that control appetite and food intake. By activating these receptors, the drug can help regulate hunger and reduce cravings, leading to decreased calorie consumption and, ultimately, weight loss. Additionally, semaglutide can slow down the emptying of the stomach, making individuals feel full for longer periods.

The drug also plays a role in improving insulin sensitivity and blood sugar control, which can be beneficial for individuals with insulin resistance or prediabetes. By addressing these underlying metabolic issues, semaglutide may contribute to overall weight loss and health improvements.

Potential Side Effects of Semaglutide

While semaglutide shows promise as a weight loss treatment, it is essential to be aware of the potential side effects associated with the drug. Common side effects may include nausea, vomiting, diarrhea, and constipation, which are often transient and improve over time as the body adjusts to the medication.

More serious side effects, although rare, can include pancreatitis, gallbladder problems, and kidney issues. It is essential to monitor for any unusual symptoms and seek medical attention if any concerning signs or symptoms arise while taking semaglutide.

Long-Term Effects and Safety Considerations

As semaglutide is a relatively new drug for weight loss, long-term effects are still being studied. While short-term trials have shown significant weight loss benefits, it is crucial to consider the potential impact of prolonged use of the medication on overall health and well-being. Close monitoring and regular follow-ups with a healthcare provider are essential for assessing the long-term safety of semaglutide.

Individuals considering semaglutide for weight loss should discuss their medical history, current medications, and any underlying health conditions with their healthcare provider before starting treatment. This will help ensure that semaglutide is a safe and appropriate option for their weight loss goals.

Conclusion

In conclusion, semaglutide presents a promising option for weight loss in non-diabetic individuals. By understanding how the drug works, being aware of potential side effects, and considering long-term safety implications, individuals can make informed decisions about incorporating semaglutide into their weight loss journey. As with any medication, it is essential to consult with a healthcare provider to determine the best course of action for achieving sustainable and healthy weight loss goals.

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