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Glad I watched that! From watching thousands of patients get sicker in standard care, to discovering the clinical leverage of peptides and reversing complex metabolic conditions, this conversation dives deep into the intersection of biology, compassion, and advanced diagnostics.

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විශේෂඥ වෛද්‍යවරයාට අනුව දියවැඩියාව සඳහා හොඳම ඖෂධය ඒවා GLP1 ඖෂධ ලෙස හැඳින්වේ, නමුත් ඉතා මිල අධිකය. ඊලගට SGLT2 ඖෂධ වේ, මෙය ඔබට මෙට්ෆෝමින් සමඟ පාලනය කළ නොහැකි නම් පමණි. විශේෂඥ වෛද්‍යවරයාට ඉන්සියුලින් මගින් අතිරික්ත කාබෝහයිඩ්‍රේට් ගබඩා කිරීමෙන් අක්මාවේ මේද ඇතිවේ. ඉන්සියුලින් සඳහා විකල්පයක්, විසදුමක්. දියවැඩියාව සඳහා ඉන්සියුලින් ගන්නා ලෙස වෛද්‍යවරයා ඉල්ලා සිටියහොත් කුමක් කළ යුතුද? බර කළමනාකරණය සහ BMI සහ ඉණ වට ප්‍රමාණය අඩු කිරීම. ආහාර සහ ව්‍යායාම: දියවැඩියා කළමනාකරණයට මූලික වන මේවා සමහර විට ඖෂධ අවශ්‍යතාවය අඩු කිරීමට හෝ නැති කිරීමට හැකිය. See references at the end of description: ඉන්සියුලින් ගැනීමට පෙර මේ ටික කරලා බලන්න මෙට්ෆෝමින්: බොහෝ විට දෙවන වර්ගයේ දියවැඩියාව සඳහා නියම කරන ලද පළමු ඖෂධය. එය අක්මාව තුළ ග්ලූකෝස් නිෂ්පාදනය අඩු කිරීමට සහ ඉන්සියුලින් සඳහා ශරීරයේ සංවේදීතාව වැඩි දියුණු කිරීමට උපකාරී වේ. Sulfonylureas: මේවා අග්න්‍යාශය වැඩි ඉන්සියුලින් මුදා හැරීමට උත්තේජනය කරයි (උදා: glipizide, glyburide). මෙග්ලිටිනයිඩ්: සල්ෆොනිලියුරියා වලට සමාන, ඒවා ඉන්සියුලින් මුදා හැරීම උත්තේජනය කරන නමුත් කෙටි ක්‍රියාකාරී වේ (උදා: රෙපග්ලිනයිඩ්, නැටෙග්ලිනයිඩ්). Thiazolidinediones: ඉන්සියුලින් සංවේදීතාව වැඩි දියුණු කිරීම (උදා: pioglitazone, rosiglitazone). SGLT2 නිෂේධක: රුධිර ප්‍රවාහයෙන් ග්ලූකෝස් ඉවත් කිරීමට වකුගඩු වලට උදව් කරන්න (උදා: canagliflozin, dapagliflozin). ඇල්ෆා-ග්ලූකෝසයිඩේස් නිෂේධක: බඩවැල්වල කාබෝහයිඩ්රේට බිඳවැටීම මන්දගාමී වේ (උදා: ඇකාබෝස්, මිග්ලිටෝල්). Weight Management and reducing BMI and Waist circumferance. Diet and Exercise: Fundamental to diabetes management, these can sometimes reduce or eliminate the need for medication. Bariatric Surgery: For some individuals with severe obesity and type 2 diabetes, bariatric surgery can significantly improve blood glucose control. Herbal and Natural Remedies: Some people use supplements such as cinnamon, berberine, or aloe vera, but these should be used with caution and under a healthcare provider's supervision. There are several alternative medications for managing diabetes, especially for those with type 2 diabetes. These alternatives include oral medications, non-insulin injectables, and other therapies. It's important to consult with a healthcare professional before making any changes to your medication regimen. Here are some commonly used alternatives: Oral Medications Metformin: Often the first medication prescribed for type 2 diabetes. It helps lower glucose production in the liver and improves the body's sensitivity to insulin. Sulfonylureas: These stimulate the pancreas to release more insulin (e.g., glipizide, glyburide). Meglitinides: Similar to sulfonylureas, they stimulate insulin release but are shorter-acting (e.g., repaglinide, nateglinide). Thiazolidinediones: Improve insulin sensitivity (e.g., pioglitazone, rosiglitazone). DPP-4 Inhibitors: Help reduce blood sugar levels without causing hypoglycemia (e.g., sitagliptin, saxagliptin). SGLT2 Inhibitors: Help the kidneys remove glucose from the bloodstream (e.g., canagliflozin, dapagliflozin). Alpha-glucosidase Inhibitors: Slow the breakdown of carbohydrates in the intestines (e.g., acarbose, miglitol). Non-Insulin Injectables GLP-1 Receptor Agonists: These mimic the incretin hormone, which increases insulin release in response to meals and slows gastric emptying (e.g., exenatide, liraglutide). Amylin Mimetics: Pramlintide is used in conjunction with insulin and helps control blood sugar by slowing gastric emptying and suppressing glucagon secretion. Other Therapies Innovative Therapies SGLT2 Inhibitors: They work by preventing the kidneys from reabsorbing sugar back into the blood, causing it to be excreted in the urine. DPP-4 Inhibitors: These help to prolong the action of incretin hormones, which increase insulin release and decrease glucagon levels after meals. Monitoring and Regular Checkups Regular Monitoring: Continuous glucose monitors (CGMs) can help track blood glucose levels more closely. Professional Support: Regular visits to a healthcare provider are crucial for adjusting treatment plans and preventing complications. References : 1. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6224890/ 2. https://www.diabetes.org.uk/

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