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To cite: Senni N, Savall M, Cabrerizo Granados D, et al. Gut 2019;68:322-334. Read the full article here: http://dx.doi.org/10.1136/gutjnl-2017-315448. Objectives: CTNNB1-mutated hepatocellular carcinomas (HCCs) constitute a major part of human HCC and are largely inaccessible to target therapy. Yet, little is known about the metabolic reprogramming induced by β-catenin oncogenic activation in the liver. We aimed to decipher such reprogramming and assess whether it may represent a new avenue for targeted therapy of CTNNB1-mutated HCC. Conclusions: FAO induced by β-catenin oncogenic activation in the liver is the driving force of the β-catenin-induced HCC. Inhibiting FAO by genetic and pharmacological approaches blocks HCC development, showing that inhibition of FAO is a suitable therapeutic approach for CTNNB1-mutated HCC.

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Have you ever asked yourself "Why am I not losing Weight?" It might be time to take a step back and instead ask yourself...Is weight loss what you really want? I ask this question because it’s key we realize that losing weight as fast as possible on the scale may actually be holding us back from seeing the fat loss results we want. Losing weight faster doesn’t mean losing fat faster. It actually often means the opposite. In our desire to see quicker changes on the scale we go to extremes which are unsustainable and only truly deplete our glycogen stores causing us to also lose water weight. It’s why we may see immediate big drops in our weight. It’s not fat being lost though. If we do manage to maintain the extreme measures, we often then also start to lose as much muscle as we do fat. And while some muscle loss will occur at points in your weight loss journey, you want to do everything possible to maintain as much lean muscle mass as you can! Join My Newsletter and Get Free Daily Fitness Tips: https://newsletter.redefiningstrength.com/ ▶️ Fat Loss Resources 5 Tips To Maintain Your Results: https://redefiningstrength.com/fhp-s2e29-5-tips-to-maintain-your-results/ How To Lose Stubborn Fat : https://youtu.be/jH5Zk8Uhgcw 3 Step Fat loss Recipe: https://rsrecipe.com Redefining Strength Podcast Channel: https://www.youtube.com/@fitnesshackspodcast Connect on social media: Instagram: @redefiningstrength Facebook: fb.com/redefiningstrength

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Hi Everyone! Today we will show some amazing back fat workout. These back fat exercises are very effective to get rid of back fat. So try these back fat workout to lose back fat effectively. ***********Subscribe Our Channel************ http://www.youtube.com/c/ZKHealthAndFitness ------------------------------------------------------------------------- #BackFatWorkout #LoseBackFat #Workout #Exercise #YoutubeShorts #Shorts *********Social Links************ Facebook: https://www.facebook.com/ZK.Health.And.Fitness/ Google+: https://plus.google.com/u/0/104447025906183052026 Twitter: https://twitter.com/zk_health **********DISCLAIMER*********** The information provided on this channel and its videos is for general purposes only and should not be considered as professional advice. We are trying to provide a perfect, valid, specific, detailed information .we are not a licensed professional so make sure with your professional consultant in case you need. All the content published in our creativity.

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Read sci-fit.net's article ► https://goo.gl/cMfvs2 Exogenous ketones have become a popular supplement in the past few years, thanks largely to the surging rise of the ketogenic diet. Promised to deliver much of what the keto diet can offer but without the consistent need to restrict carbs, ketone supplements have become a marketing miracle in very short order. But does it live up to any of its hype? Fat loss? Ketosis? Performance? Let's find out. *************************************************************** Support PictureFit! MERCH! ► https://picfitshop.com Patreon ► https://goo.gl/lmsWf7 Amazon Affiliate (I get a kickback. No added charge!) ► https://goo.gl/FLN5pw *************************************************************** Come join PictureFit! Facebook ► https://www.facebook.com/PictureFitYT/ Twitter ► https://twitter.com/Picture_Fit Instagram ► https://instagram.com/picturefit/ Please Like and Subscribe! *************************************************************** Awesome PF Patrons Wall: Anime Jesus! mr.awesome03 Hugo Håkansson References: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5556006/ http://www.nrcresearchpress.com/doi/abs/10.1139/apnm-2017-0724#.WyIuY0gvwcF https://www.frontiersin.org/articles/10.3389/fphys.2017.00310/full https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5440563/ https://researchcommons.waikato.ac.nz/handle/10289/11199 https://www.ncbi.nlm.nih.gov/pubmed/3392162 Music by Chillhop: http://chillhop.com/listen j'san - good morning sunshinehttps://soundcloud.com/iamjsan/ Listen on Spotify: http://bit.ly/ChillhopSpotify Picturefit on YouTube! I share some of my health and fitness tips with you. Come check out our content! New fitness topics on a weekly basis. Want to learn about more health and fitness topics? Ask it in the comments! Learn all you need to know and what to do at the gym. Learn about aerobics, strength, hypertrophy, power, and endurance! Any information in these videos should not be taken as personal healthcare advice. If you have questions about your health, please speak directly to your personal healthcare professional.

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Struggling to lose fat even though you eat clean and train hard? The secret is simple: calorie deficit. No deficit, no fat loss — it’s that straightforward. If your diet feels too easy, you’re not cutting enough. Get comfortable being uncomfortable and watch your results skyrocket. 💥 #FatLoss #CalorieDeficit #FitnessTips #Cutting #fatlosstips

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Full-Body Fat Burning Workouts (NO JUMPING!) #abs Struggling to lose fat and tone your body? This Full-Body Fat Burning Workout is perfect for you! Designed with low-impact exercises and no jumping, it’s gentle on your joints but still highly effective for burning calories and strengthening your core. Whether you're a beginner or looking for a quiet workout option, this routine is ideal for home workouts or when you want to avoid high-impact moves. Plus, it focuses on building your abs, improving strength, and promoting fat loss all over your body. 👉 What’s Included in This Workout: Low-impact, full-body exercises. Core-strengthening movements targeting your abs. Fat-burning routines suitable for all fitness levels. Key Benefits of This Workout: 1. Burns calories and promotes fat loss without intense jumping. 2. Helps build and tone abdominal muscles for a stronger core. 3. Ideal for people with joint issues or those in need of a quieter routine. 4. Can be done anytime and anywhere with no equipment needed. 🔑 Tips for Best Results: Maintain proper form during each exercise to avoid injury and maximize results. Pair this workout with a balanced, healthy diet. Stay consistent and aim to complete this routine 3–4 times a week. This low-impact workout is proof that you don’t need to jump or perform high-intensity moves to burn fat and tone your body. Let’s achieve your fitness goals together! Don’t forget to LIKE, COMMENT, and SUBSCRIBE for more low-impact workout routines and fitness tips. Hit the bell icon so you never miss an update! YouTube channel link:-https://youtube.com/@Rush4funvlogs?si=ygmgaSX6HTEvg-eP #home workout, #weight loss, #gym alternatives, #bodyweight workout, #calisthenics workout, #home gym reviews, #ab workout, #full body, #bodyweight training, #home gym, #functional training, #weight loss tips, #workout at home, #strength training, full body workout, caroline girvan abs

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Mini Vlog Day 49/60 of my weight loss Journey. #weightlossjourney #shorts #exercise #workout #minivlog #shorts #short #video #viral #trending #exercise #workout #weightloss #weightlossjourney #weightlosstips #weightlosstransformation #75hardchallenge #90dayschallenge ‎@Lifewithsunitavlogs  #Lifewithsunitavlogs