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Imagine a treatment that not only helps manage diabetes but also holds the potential to reverse kidney failure — what was once thought to be impossible. The recent FLOW study has remarkable groundbreaking evidence that GLP-1 receptor agonists can significantly improve kidney function in chronic kidney disease (CKD) patients. And while researchers try to understand the full implications of these findings, one thing is clear: the landscape of kidney disease treatment may never be the same again. In this podcast, we’ll dive into the results of the FLOW trial and explore what they may mean for people at risk for kidney failure. What are GLP-1 Agonists? GLP-1 (glucagon-like peptide-1) agonists are a class of drugs that mimic the effects of the natural hormone GLP-1. They enhance insulin secretion, inhibit glucagon release, and slow gastric emptying, improving blood sugar control. Beyond their primary use in diabetes management, GLP-1 agonists have been studied for various conditions, including obesity and cardiovascular disease prevention. The Study Overview The FLOW trial, which stands for "Fasting and Long-acting GLP-1 Receptor Agonist in Patients with Chronic Kidney Disease," focused on the impact of GLP-1 receptor agonists, specifically semaglutide, on patients with chronic kidney disease (CKD) and type 2 diabetes (those most at risk for kidney failure). Researchers observed a remarkable trend: patients receiving semaglutide demonstrated stabilization of kidney function and signs of renal recovery. This was groundbreaking, as reversing kidney damage has long been considered a near-impossible feat. Study Objectives The primary goal was to determine whether treatment with GLP-1 receptor agonists could improve kidney outcomes in patients with CKD. Study Design Participants: The study enrolled >3500 adults with type 2 diabetes and CKD. Intervention: Participants were randomized to receive either semaglutide or a placebo. Primary Outcomes: The main outcomes included changes in glomerular filtration rate (GFR) and the incidence of major adverse kidney events (kidney failure- need for transplantation or dialysis). Key Findings Renal Function Improvement: Patients on semaglutide showed significant improvements in glomerular filtration rates (GFR), a key indicator of kidney function. Reduced Inflammation: The drugs appeared to lower levels of inflammatory markers associated with kidney damage, suggesting a protective effect. Metabolic Benefits: Improvements in blood sugar control and weight loss were also observed, contributing to overall health and potentially alleviating stress on the kidneys. Adverse Events: The treatment was generally well-tolerated, with a favorable safety profile. Ethical Considerations As the results began to emerge, the ethical landscape of the study shifted dramatically. The control group, which was not receiving semaglutide, was found to be at a significantly higher risk of kidney deterioration. With compelling evidence that the GLP-1 agonist was safe and potentially life-saving, the ethics committee determined withholding treatment from any participants was no longer justifiable. Consequently, the study was halted prematurely to allow all participants access to the medication, prioritizing patient welfare over the continuation of research under an inequitable framework. This decision underscores the ethical responsibility of researchers to ensure that all patients receive the best possible care, especially when clear benefits are identified. Implications for Future Research While the early termination of the study raises questions about the completeness of the data collected, it also opens new avenues for further research. The findings encourage more extensive clinical trials to explore the mechanisms behind the renal protective effects of GLP-1 agonists. Additionally, there is a growing interest in investigating these drugs' long-term effects on kidney health and their potential role in preventing disease progression. As further studies unfold, there is hope that GLP-1 agonists will become a standard part of kidney disease management, potentially transforming outcomes for millions affected by this condition. Thanks again for listening to The Peptide Podcast. We love having you as part of our community. If you love this podcast, please share it with your friends and family on social media, and have a happy, healthy week! We're huge advocates of elevating your health game with nutrition, supplements, and vitamins. Whether it's a daily boost or targeted support, we trust and use Momentous products to supercharge our wellness journey. Momentous only uses the highest-quality ingredients, and every single product is rigorously tested by independent third parties to ensure their products deliver on their promise to bring you the best supplements on the market.
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Leftovers from last night’s dinner were exactly what my body needed today for lunch. 😋 So delicious and satisfying! A lot of you ask me how I prep my body for my GLP-1 injection days, and I’ve found a routine that works so well for me. Sharing it here because feeling good is the goal, right? ✨ Here’s what I’ve been doing since I started: ✅ High protein the day before AND two days after (yes, more than your usual protein goal!) ✅ Staying hydrated like it’s my full-time job 💧 ✅ If you’re early in your journey, don’t hesitate to take Zofran to help with nausea. It makes a world of difference! Your body deserves care, consistency, and nourishment. How are you prepping for your next injection day? Let me know below if you have a go-to tip or trick that’s helped you on your GLP-1 journey! 💬 #glp1 #glp #semaglutide #tirzepatide #insulinresistance #diabetes #pcos #inflammationrelief #momsoftiktok
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What is Ozempic? Ozempic (semaglutide) is used for type 2 diabetes in adults to improve blood sugar levels and also used to lower the risk of major cardiovascular events like stroke, heart attack or death, for adults with type 2 diabetes with heart disease. In clinical trials, Ozempic has also been shown to help with weight loss, after 30 weeks, patients on Ozempic 0.5mg had lost 2.6 kg more than the placebo group, and patients on Ozempic 1mg lost 3.5 kg more than the placebo group. Although currently, Ozempic is not an FDA-approved weight loss medicine. Ozempic works to lower blood sugar, helping the pancreas make more insulin, decreasing the amount of sugar your liver makes, and slowing the rate food passes through your body, making you feel full longer. Ozempic is from a class of medicines called a glucagon-like peptide-1 (GLP-1) agonists (incretin mimetics) that works by binding to GLP-1 receptors which results in lower blood sugar levels and A1C levels and may also reduce your appetite to help weight loss. Ozempic is a once-weekly injection that should be used along with diet and exercise. Ozempic should not be used for type 1 diabetes mellitus. Other brands of semaglutide. Ozempic (semaglutide) contains the same active ingredient as: Wegovy injections which is FDA approved for weight loss in adults and teenagers who have obesity, or adults who are overweight (excess weight) and also have weight-related medical problems. Rybelsus tablets, which are FDA approved to lower blood sugar levels for type 2 diabetic patients along with diet and exercise. Ozempic side effects Common Ozempic side effects low blood sugar (in people with type 2 diabetes); upset stomach, heartburn, burping, gas, bloating; nausea, vomiting, stomach pain, loss of appetite; diarrhea, constipation; runny nose or sore throat; stomach flu symptoms; or headache, dizziness, tiredness. Serious Ozempic side effects. Get emergency medical help if you have signs of an allergic reaction: hives, itching; dizziness, fast heartbeats; difficult breathing; swelling of your face, lips, tongue, or throat. Call your doctor at once if you have: vision changes; unusual mood changes, thoughts about hurting yourself; pounding heartbeats or fluttering in your chest; a light-headed feeling, like you might pass out; signs of a thyroid tumor--swelling or a lump in your neck, trouble swallowing, a hoarse voice, feeling short of breath; symptoms of pancreatitis--severe pain in your upper stomach spreading to your back, nausea with or without vomiting, fast heart rate; gallbladder problems--upper stomach pain, fever, clay-colored stools, jaundice (yellowing of the skin or eyes); low blood sugar--headache, hunger, weakness, sweating, confusion, irritability, dizziness, fast heart rate, or feeling jittery; kidney problems--swelling, urinating less, blood in urine, feeling tired or short of breath stomach flu symptoms--stomach cramps, vomiting, loss of appetite, diarrhea (may be watery or bloody) symptoms of ileus (stomach paralysis)--bloating, stomach cramps or pain, nausea or vomiting, constipation or diarrhea, loss of appetite. How should I use Ozempic? Use this medicine exactly as prescribed by your doctor. Follow all directions on your prescription label and read all medication guides or instruction sheets. It is usually started at a low dose that is gradually increased every 4 weeks to 30 days. Follow your doctor's dosing instructions very carefully, and ask your doctor or pharmacist if you need help. Ozempic is injected under the skin (subcutaneous injection), usually once per week at any time of the day, with or without food. Use an injection on the same day each week. Prepare an injection only when you are ready to give it. Call your pharmacist if the medicine looks cloudy, has changed colors, or has particles in it. Your healthcare provider will show you where to inject this medicine, it is usually injected into the abdomen, thigh, or upper arm. Do not inject into the same place two times in a row. ozempic injection how to use, ozempic weight loss, ozempic weight loss before and after, ozempic side effects, ozempic weight loss stories, ozempic results, ozempic injection, ozempic face, ozempic before and after, ozempic injection how to use for weight loss, ozempic injection price in pakistan ozempic how to use, ozempic price in pakistan, #ozempic #ozempicweightloss
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