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We know they are expensive, but isn’t the cost recouped by the healthcare savings? Dr F. Perry Wilson explains. https://www.medscape.com/viewarticle/glp-1s-are-crazy-effective-just-not-cost-effective-2025a10006es?src=soc_yt --TRANSCRIPT-- Welcome to Impact Factor, your weekly dose of commentary on a new medical study. I’m Dr F. Perry Wilson from the Yale School of Medicine. Much of my time in these videos is spent talking about whether a drug or supplement or diet or intervention works or not. That’s the central focus of medical science: Can we do something for a patient and make a difference in their health? But there’s a related question that we rarely discuss that is almost equally as important: Is this drug or supplement or diet or intervention worth it? And I don’t mean “worth it” in some meta-physical sense. I mean "worth it" in terms of dollars and cents. Is the cost we pay for something worth the benefit we derive from it? I’ll make the argument that the most effective drugs in the past decade are the GLP-1 receptor agonists, drugs like semaglutide and tirzepatide. At least in terms of weight loss, they are truly unparalleled. They are clearly effective. But are they worth it? Are they cost-effective? That is a much harder question, and, as you’ll see in a minute, despite their amazing effects, the answer — for now, at least — is no. How do we decide if a drug is cost-effective? What does that even mean? I’ll give you some extreme examples to illustrate the point a bit. First, for it even to be possible that a drug is cost-effective, it must be effective. It must improve health in some clear, measurable way. Pink jelly beans, while quite inexpensive, do not improve health at all and are therefore not cost-effective. Policymakers should not advocate that insurers cover pink jelly beans. On the flip side are drugs and interventions that actually make money for the system — things that are so good for you, they save money in the long term. The childhood vaccination program is probably the best example of this. The CDC estimates that for every $1 spent on the program, the payer saves about $3 in future costs and society saves about $10 in future costs. This is why insurers have no problem covering childhood vaccines; they would literally be leaving money on the table if they didn’t. So those are the extremes. Don’t pay for pink jelly beans, do pay for vaccines. But we don’t think it is appropriate to cover only stuff that saves money. We are willing to trade money for longer life or quality of life. And this is where the rubber meets the road when it comes to cost-effectiveness analysis: How much is your life worth? To an economist, the answer is basically $100,000 per year of perfect health. The ways they arrive at this number are pretty fascinating, but a lot of it is done by looking at what we as a society are willing to pay for. A cost of $100,000 per “quality-adjusted life year” (QALY) is our standard candle here. More than that is not particularly cost-effective. Less than that is. The “quality” in the QALY is important too. Economists know that a year of perfect health is worth more, in dollar terms, than a year of moderate or poor health. So, if we take an intervention and do some clever modeling based on the price of the intervention and its effectiveness at improving health, we can tell you how much it costs per QALY. Here are a few examples. We have an intervention to pay people to quit smoking. This costs about $2500 per QALY. Seems pretty good. Transcript in its entirety can be found by clicking here: https://www.medscape.com/viewarticle/glp-1s-are-crazy-effective-just-not-cost-effective-2025a10006es?src=soc_yt

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Grüner Tee wird aufgrund seiner zahlreichen gesundheitlichen Vorteile und seiner Fähigkeit, beim Abnehmen zu helfen, immer beliebter. Viele Menschen fragen sich jedoch, ob es besser ist, grünen Tee warm oder kalt zu trinken, um die besten Ergebnisse zu erzielen. In diesem Artikel werden wir diese Frage genauer untersuchen und herausfinden, ob es einen Unterschied macht, wie grüner Tee konsumiert wird, wenn es um Gewichtsabnahme geht.

Die Wirkung von grünem Tee auf den Stoffwechsel

Grüner Tee enthält eine Vielzahl von Antioxidantien und nützlichen Pflanzenstoffen, die dazu beitragen können, den Stoffwechsel zu steigern. Eine der Schlüsselkomponenten im grünen Tee ist das Katechin Epigallocatechingallat (EGCG), das nachweislich die Fettverbrennung fördert und den Körper dabei unterstützt, Kalorien effizienter zu verbrennen. Studien haben gezeigt, dass Menschen, die regelmäßig grünen Tee trinken, tendenziell einen schnelleren Stoffwechsel haben als diejenigen, die keinen grünen Tee konsumieren. Dies kann dazu beitragen, das Abnehmen zu erleichtern und den Gewichtsverlust zu beschleunigen.

Ein weiterer wichtiger Aspekt des grünen Tees ist seine Fähigkeit, den Blutzuckerspiegel zu regulieren. Wenn der Blutzuckerspiegel stabil ist, fühlen wir uns länger satt und haben weniger Heißhungerattacken. Durch den Konsum von grünem Tee kann man also möglicherweise Kalorien einsparen und somit einfacher abnehmen. Es ist jedoch wichtig zu beachten, dass grüner Tee allein keine Wunder bewirkt und dass eine gesunde Ernährung und ausreichend Bewegung entscheidend sind, um Gewicht zu verlieren.

Es gibt Hinweise darauf, dass das Trinken von grünem Tee den Fettstoffwechsel verbessern und die Fettverbrennung während des Trainings fördern kann. Durch die Kombination von grünem Tee mit körperlicher Aktivität können möglicherweise bessere Ergebnisse erzielt werden als bei der alleinigen Ausübung von Sport. Einige Experten empfehlen, vor dem Training grünen Tee zu trinken, um den Stoffwechsel anzuregen und die Fettverbrennung zu steigern.

Warm oder kalt: Welche ist die bessere Option?

Eine häufig gestellte Frage ist, ob grüner Tee besser warm oder kalt getrunken werden sollte, um die abnehmenden Vorteile zu maximieren. Die Antwort auf diese Frage ist nicht ganz so einfach, da es verschiedene Faktoren zu berücksichtigen gibt. Einige Menschen bevorzugen warmen grünen Tee, da er beruhigend wirkt und besonders an kalten Tagen angenehm ist. Andere schwören darauf, grünen Tee kalt zu trinken, da er erfrischend ist und an heißen Tagen eine willkommene Abkühlung bietet.

Es gibt jedoch Hinweise darauf, dass warmer grüner Tee möglicherweise effektiver beim Abnehmen ist als kalter grüner Tee. Warmes Wasser hilft dem Körper, sich schneller zu erwärmen und den Stoffwechsel zu beschleunigen. Dies kann dazu beitragen, dass der grüne Tee seine Wirkung auf den Stoffwechsel verstärkt und somit beim Abnehmen hilft. Es ist daher möglich, dass warmes grüner Tee besser geeignet ist, um die abnehmenden Vorteile des Tees zu nutzen.

Auf der anderen Seite haben Studien gezeigt, dass kalt getrunkenes grüner Tee ebenfalls positive Auswirkungen auf den Stoffwechsel haben kann. Kalter grüner Tee kann den Körper möglicherweise dazu anregen, mehr Energie zu verbrauchen, um das kalte Getränk auf Körpertemperatur zu erwärmen. Dieser zusätzliche Energieverbrauch kann dazu beitragen, dass mehr Kalorien verbrannt werden und somit beim Abnehmen helfen. Letztendlich kann die Wahl zwischen warmem und kaltem grünen Tee eine Frage des persönlichen Geschmacks und der Vorlieben sein.

Tipps zur Zubereitung von grünem Tee

Unabhängig davon, ob Sie Ihren grünen Tee warm oder kalt bevorzugen, gibt es einige Tipps zur Zubereitung, um sicherzustellen, dass Sie die maximalen gesundheitlichen Vorteile aus Ihrem Tee ziehen. Erstens ist es wichtig, hochwertigen grünen Tee zu wählen, um sicherzustellen, dass er reich an den wertvollen Antioxidantien und Katechinen ist, die für die Gewichtsabnahme förderlich sind.

Zweitens ist die richtige Zubereitung des grünen Tees entscheidend. Für warmen grünen Tee sollte das Wasser nicht kochend heiß sein, da dies die empfindlichen Inhaltsstoffe des Tees zerstören kann. Idealerweise sollte das Wasser auf etwa 80 Grad Celsius abgekühlt werden, bevor man es über den Tee gießt. Für kalt getrunkenen grünen Tee kann der Tee über Nacht im Kühlschrank ziehen gelassen werden, um ein volleres Aroma zu erreichen.

Ein weiterer wichtiger Tipp ist, den grünen Tee nicht zu lange ziehen zu lassen, da dies zu einem bitteren Geschmack führen kann. In der Regel reichen 2-3 Minuten aus, um die vollen gesundheitlichen Vorteile des grünen Tees zu erhalten. Durch die Beachtung dieser Tipps können Sie sicherstellen, dass Ihr grüner Tee nicht nur lecker schmeckt, sondern auch dazu beiträgt, Ihre Gewichtsabnahmeziele zu unterstützen.

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I spend a LOT of time trying to make my videos as concise, polished, and useful as possible for you - if you would like to support me on that mission then consider subscribing to the channel - you'd make my day 😁 _________________________________________________ My Favourite (You can support me with these links) Sport Mat: https://amzn.to/4ejhBNT Foam Roller (big size): https://amzn.to/4b1jCv3 Gun Massage: https://amzn.to/3VrvL71 Jump Rope: https://amzn.to/3VyQFkK ______________________________________________________ Instagram: https://www.instagram.com/kamran_spor... Twitter: https://twitter.com/k_hosseinzadeh Tiktok: https://www.tiktok.com/@kamran_sportslab Location: Berlin, Germany DISCLAIMER: This content (the video, description, links, and comments) is not medical advice or a treatment plan and is intended for general education and demonstration purposes only. This content should not be used to self-diagnose or self-treat any health, medical, or physical condition. Don’t use this content to avoid going to your own healthcare professional or to replace the advice they give you. Consult with your healthcare professional before doing anything contained in this content. The content in this video is for informational and educational purposes only. We are not medical professionals, so please consult with a healthcare provider before starting any exercise program. Participate at your own risk, and stop if you experience any pain or discomfort. We are not liable for any injuries or damages resulting from this video. Prioritize your safety and well-being at all times. Thank you for understanding. #Sporttherapy #SportMedicine #SportPhysicaltherapy