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Ozempic (semaglutide) is a prescription medication that belongs to the class of drugs known as glucagon-like peptide-1 (GLP-1) receptor agonists. In this video, we explore how Ozempic works by mimicking the effects of the naturally occurring hormone GLP-1 to regulate blood sugar levels and appetite. Learn about the role of GLP-1, an incretin hormone produced in the gut, in signaling the pancreas to produce and release insulin and inhibit glucagon production. Discover how Ozempic, as a GLP-1 receptor agonist, enhances these effects, leading to increased insulin secretion, decreased glucagon secretion, slowed gastric emptying, and reduced appetite. We'll discuss the combined effects of these actions, which lead to significant improvements in glycemic control, as demonstrated in clinical trials. Patients with Type 2 Diabetes treated with Ozempic experienced reduced HbA1c levels, lower fasting blood sugar levels, and improved post-meal glucose levels compared to placebo or other diabetes medications. Additionally, we'll touch on the potential cardiovascular benefits of Ozempic in adults with Type 2 Diabetes and established cardiovascular disease, and briefly introduce the growing interest in its use for weight management. Stay tuned for the next video, where we'll explore the trend of off-label use of Ozempic for weight loss and its relation to Wegovy, a semaglutide-based medication specifically designed for weight management.

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The diabetes and weight loss drug semaglutide significantly reduced symptoms and improved quality of life in people with obesity and the most common form of heart failure in a clinical trial, potentially expanding the already wildly popular drug’s use beyond diabetes and weight loss and offering a new treatment option where few are available. Dr. Mikhail Kosiborod, cardiologist and vice president for research at Saint Luke’s Mid America Heart Institute, was the lead author of the study and presented the findings of STEP-HFpEF trial during the opening late breaking clinical trial session at the European Society of Cardiology Congress (ESC Congress)—the world’s largest cardiology conference— in Amsterdam, Netherlands. The study of 529 patients found that a 2.4-milligram weekly dose of semaglutide led to an improvement of 17 points on a 100-point scale that’s used to assess symptoms of a condition known as heart failure with preserved ejection fraction. By comparison, participants who got a placebo had a 9-point improvement. The study was published Friday in the New England Journal of Medicine. Learn more about Saint Luke's: https://www.saintlukeskc.org/hfpef-trial-obesity-medication-proves-effective-treating-patients-heart-failure Connect: https://www.facebook.com/saintlukeskc https://twitter.com/saintlukeskc https://www.instagram.com/saintlukeskc/