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REFERENCE for Curious Interested Listeners & Physicians 48,25mar In Part 2 of our deep dive into Mounjaro vs. Ozempic, we’re busting myths and uncovering what doctors aren’t always saying. Here’s what we’ll cover: • Myth 1: “All GLP-1 drugs are the same.” • Reality: Ozempic targets a single pathway, while Mounjaro works on two—leading to potential greater weight loss in some, but it’s not a one-size-fits-all. • Myth 2: “These drugs only make you eat less.” • Reality: They also influence the brain’s reward system, reducing cravings and the emotional drivers of eating, not just physical hunger. We’ll break down how these medications work, the real-world impact, and why individual responses vary. Stay tuned Part 3 for more insights into what doctors might not be telling you about these weight loss treatments! 1. Animal Studies Alhadeff AL, Rupprecht LE, Hayes MR. (2012). Glucagon-like peptide-1 receptor signaling in the ventral tegmental area attenuates food intake. Journal of Neuroscience, 32(25), 8112-8120. Showed GLP-1 drugs reduce food-seeking behavior by acting on brain reward areas. 2. Brain Reward Pathways Dickson SL, Shirazi RH, Hansson C, et al. (2012). The role of GLP‑1 receptor activation in the central regulation of energy balance and reward. Physiology & Behavior, 106(2), 231–238. Explains how GLP-1 receptors in the brain influence eating for pleasure, not just hunger. 3. Incretin Hormones Review Nauck MA & Meier JJ. (2018). Incretin hormones: Their role in health and disease. Diabetes, Obesity and Metabolism. Details the dual role of GLP-1 in gut and brain signaling. 4. The SURPASS-2 Trial Jastreboff, A. M., et al. (2022). Tirzepatide versus Semaglutide Once Weekly in Patients with Type 2 Diabetes (SURPASS-2): A Randomized, Open-Label, Parallel-Group, Phase 3 Trial. This study and provided weight loss data for both tirzepatide (Mounjaro) and semaglutide (Ozempic). 5. The SURPASS Clinical Trials (Review and Meta-Analysis) Frías, J. P., et al. (2022). Insights from the SURPASS Clinical Trials: A Systematic Review and Meta-Analysis of Tirzepatide in Type 2 Diabetes. Diabetes, Obesity and Metabolism. Discusses how the additional GIP receptor activity might contribute to enhanced weight loss. 6. Eli Lilly (Mounjaro) https://www.lilly.com/news/media/media-kits/mounjaro https://mounjaro.lilly.com 7. Novo Nordisk (Ozempic) https://www.novonordisk.com.au/our-products-for-healthcare-professionals.html https://rss.medsinfo.com.au/no/pi.cfm?product=nopozemp

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