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Do Diet Breaks Enhance Metabolism? The concept of diet breaks began gaining popularity around 20 years ago with the concept of refeed days or calorie cycling. The idea that instead of eating the same amount of calories every day on a diet, you could do periods of lower & higher calories & perhaps this would help improve fat loss, muscle retention, & perhaps stave off metabolic adaptation. Metabolic adaptation refers to the slowing of metabolic rate beyond what is expected that occurs with weight loss. A study in 2018 called the “MATADOR Study” showed a significant attenuation of metabolic slowing using 2 week diet phases followed by 2 week diet break phases where people ate at maintenance. The diet break group also had better fat loss efficiency & lean mass retention. Subsequent studies however, failed to replicate some of these results This leads us to the meta-analysis being discussed today that attempted to come to a consensus of the literature examining people utilizing diet breaks (periods of eating at maintenance or more during a fat loss diet) vs those following continuous energy restriction (CER). PMID: 38193357 The researchers found that on average, utilizing diet breaks led to about a 50 kcal per day reduction in metabolic adaptation compared with CER & this was a statistically significant effect. However, there were no differences between CER & diet breaks for fat free mass retention or fat loss What is the take home? Diet breaks may help reduce metabolic slowing compared to normal dieting, but the effect is relatively small at ~50 kcal per day. So if you don’t like using diet breaks & prefer to just eat the same way every day, it’s probably not worth trying to force yourself to do diet breaks. But if you like diet breaks, then the attenuation of metabolic adaptation might be a nice bonus Get my research review REPS: biolayne.com/REPS Get my new nutrition coaching app, Carbon Diet Coach: http://onelink.to/9h4d62 My research based supplements: http://www.outworknutrition.com Get my books on how to lose fat: http://www.biolaynestore.com Take my online course "The Science of Nutrition": https://chfi.click/laynenorton_online Get Custom Workouts by me for $12.99/month: https://biolayne.com/workout-builder/ http://www.facebook.com/laynenorton http://www.twitter.com/biolayne http://www.instagram.com/biolayne

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The Servier pharmaceutical group was found guilty by a Paris court on Monday, as the trial over one of the biggest health scandals to have hit France came to a close. More than ten years after the opening of a judicial investigation and eighteen months after the start of the trial, the drugmaker was found guilty of involuntary manslaughter and aggravated fraud for selling the weight loss pill 'Mediator,' which was blamed for hundreds of deaths. "It was a historic trial, it becomes for me, a historic judgment. Even if it is not entirely satisfactory, it is nonetheless true that this is the first time that a laboratory has been so severely condemned," said victims' lawyer Jean-Christophe Coubris. "I hope that the laboratories will hear both the suffering of the victims and the condemnation that has been pronounced against the Servier laboratories," the lawyer added. "Servier laboratories are ordered to pay the victims around 160 million euros (188 million USD). This is extremely low compared to the real profit made by the Mediator, around 400 million euros (470,9 million USD) during the 14 years of undue marketing," said Charles-Joseph-Oudin, lawyer of Michel Due, one of the victims. Servier was also sentenced to a fine of 2.7 million euros (3,18 million USD). Jean-Philippe Seta executive of Servier pharmaceutical group was sentenced to four years of suspended imprisonment, as well as a fine of 90,600 euros (106,67 USD). At least 500 people died of heart valve problems due to the Mediator's active ingredient, according to France's health ministry. The drug was on the market for 33 years before it was pulled in 2009. Credit: Ruptly #pharma #servier #mediator

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