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Embark on an eye-opening exploration of the remarkable transformation of GLP-1 drugs, from their origins as diabetes treatments to their groundbreaking applications in tackling obesity.

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Dr. Zachary Knight and Dr. Andrew Huberman discuss the development of GLP-1 drugs like Ozempic for diabetes and weight loss, examining their historical origins, biological mechanisms, and impact on appetite and metabolism. Dr. Zachary Knight is a professor of physiology at the University of California, San Francisco (UCSF), and Howard Hughes Medical Institute (HHMI) investigator. Dr. Andrew Huberman is a tenured professor of neurobiology and ophthalmology at Stanford University School of Medicine and host of the Huberman Lab podcast. Watch the full episode: https://youtu.be/C5KpIXjpzdY Show notes: https://www.hubermanlab.com/episode/dr-zachary-knight-the-science-of-hunger-medications-to-combat-obesity Timestamps 00:00 Introduction to Weight Loss Challenges 00:06 The Discovery of GLP-1 & Its Origins 01:35 Understanding the Incretin Effect 02:58 The Role of GLP-1 in Diabetes Treatment 04:39 Challenges & Innovations in GLP-1 Drug Development 05:52 Breakthroughs in GLP-1 Drugs for Weight Loss 10:47 Mechanisms of GLP-1 Drugs in the Brain 13:39 Conclusion & Further Insights #HubermanLab #Science #GLP1 Disclaimer & Disclosures: https://www.hubermanlab.com/disclaimer

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Interventions like ketogenic metabolic therapy (aka ketogenic diet) are being used to treat serious mental illnesses like major depression, bipolar and schizophrenia. Georgia Ede, MD is a pioneer in Metabolic Psychiatry, and has used a ketogenic diet to help hundreds of patients improve their symptoms of mental illess. Dr. Georgia Ede is a Harvard-trained psychiatrist and worldwide expert in nutritional psychiatry. Dr. Ede has over a decade of real-world experience using nutrition as a treatment for mental illness. In her talk, she describes her real-world experience using ketogenic metabolic interventions to restore brain function in psychiatric disorders. Bio: https://www.diagnosisdiet.com/about Twitter: @GeorgiaEdeMD This video was recorded at the first ever Metabolic Psychiatry roadmap retreat, hosted by Baszucki Group and the Milken Institute for Strategic Philanthropy in May, 2022 in Santa Barbara. The conference brought together physicians, neuroscientists, dieticians, entrepreneurs, venture capitalists and philanthropists to build community in the emerging field of Metabolic Psychiatry. Learn more about metabolic psychiatry and meet the visionary Metabolic Mind Award Winners at https://tinyurl.com/Baszucki-Group About us: Metabolic Mind™ is a nonprofit initiative incubated by Baszucki Group. Our mission over time will be to provide resources and build community in metabolic psychiatry. JOIN OUR MAILING LIST AT https://metabolicmind.org/ Other resources for Metabolic Psychiatry, metabolic neuroscience and ketogenic metabolic therapy for mental disorders: Diagnosis Diet - https://www.diagnosisdiet.com/ New Study: Serious Mental Illness Improves on Ketogenic Diet - https://www.psychologytoday.com/us/blog/diagnosis-diet/202207/new-study-serious-mental-illness-improves-ketogenic-diet The Role of Ketogenic Metabolic Therapy on the Brain in Serious Mental Illness: A Review https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9728807/ Chris Palmer MD - https://www.chrispalmermd.com/ Stanford Metabolic Psychiatry- https://metabolicpsychiatry.com/ What Is Metabolic Psychiatry? 5 Questions Answered by Dr. Shebani Sethi https://med.stanford.edu/news/all-news/2022/11/metabolic-psychiatry.html Baszucki Group - https://baszuckigroup.com/our-work/metabolism-mental-health/ BipolarCast: Keto + Bipolar youtube channel, Hosted by Matt Baszucki and Iain Campbell, PhD https://www.youtube.com/channel/UCDB-iMvEJ-HeHqpamIN5JWw https://twitter.com/IainCampbellPhD Our channel is for informational purposes only. We are not providing individual or group medical or healthcare advice nor establishing a provider-patient relationship. Many of the interventions we discuss can have dramatic or potentially dangerous effects if done without proper supervision. Consult your healthcare provider before changing your lifestyle or medications. #MetabolicMind #KetoForMentalHealth #MetabolicPsychiatry #BipolarTreatment #MetabolicNeuroscience #KetogenicMetabolicTherapy #NutritionalKetosis #MentalIllnessTreatment #MentalHealthIsMetabolicHealth

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Semaglutide is a medication that has been gaining attention for its potential use in weight loss. Originally developed to treat type 2 diabetes, semaglutide has shown promising results in helping individuals shed excess pounds. However, determining the right dose of semaglutide for weight loss can be a crucial factor in achieving successful outcomes.

The Importance of Finding the Right Dose

When it comes to using semaglutide for weight loss, finding the right dose is essential for optimizing results while minimizing potential side effects. The dosage of semaglutide can vary depending on individual factors such as weight, age, and medical history. Too high of a dose may lead to adverse reactions, while too low of a dose may not provide the desired weight loss benefits.

With the increasing prevalence of obesity and related health problems, there is a growing need for effective weight loss solutions. Semaglutide offers a promising option for individuals struggling to lose weight, but finding the right dose is key to unlocking its full potential.

By understanding the factors that influence the effectiveness of semaglutide for weight loss and working closely with healthcare providers to determine the optimal dosage, individuals can increase their chances of successful weight loss outcomes.

Factors to Consider in Determining the Right Dose

Several factors come into play when determining the appropriate dose of semaglutide for weight loss. These include the individual’s current weight, medical history, and response to the medication. Healthcare providers will assess these factors to tailor a dosage regimen that is safe and effective for each person.

In addition to individual factors, the specific formulation of semaglutide being used can also influence the optimal dose for weight loss. Different formulations may have varying potencies and dosing schedules, so it is important to follow healthcare provider recommendations closely.

Monitoring and adjusting the dose of semaglutide over time is also essential for maximizing weight loss benefits. Regular check-ins with healthcare providers can help ensure that the dosage remains appropriate and effective throughout the weight loss journey.

Potential Side Effects and Risks

Like any medication, semaglutide for weight loss can come with potential side effects and risks. Common side effects may include nausea, diarrhea, and constipation, especially when starting the medication or increasing the dose. These side effects are usually mild and temporary but should be monitored closely.

In rare cases, more serious side effects such as pancreatitis or thyroid tumors may occur with the use of semaglutide. It is important to be aware of these risks and discuss any concerns with healthcare providers before starting treatment.

Individuals with a history of certain medical conditions, such as pancreatitis or thyroid disorders, may be at higher risk for experiencing adverse effects with semaglutide. Healthcare providers will take these factors into consideration when determining the appropriate dose and monitoring for potential complications.

Tips for Success with Semaglutide

To maximize the effectiveness of semaglutide for weight loss, there are some tips that individuals can follow. These include following a healthy diet and exercise plan, staying in regular contact with healthcare providers, and monitoring any changes in weight or symptoms carefully.

It is important to be patient and consistent when using semaglutide for weight loss, as results may take time to manifest. Setting realistic goals and tracking progress can help individuals stay motivated and on track with their weight loss journey.

By taking a proactive approach to managing dosage, side effects, and overall well-being, individuals can increase their chances of success with semaglutide for weight loss. Working closely with healthcare providers and staying informed about potential risks and benefits are key components of a safe and effective weight loss plan.

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91st Week Weigh-In: Discovering the Benefits and Challenges of GLP-1 Medications In the latest episode of 'The Downsized,' hosts Laraine and Christopher Durham reflect on their 91-week journey with GLP-1 medications Tirzepatide, Zepbound & Wegovy. They've collectively lost over 150 pounds, with Laraine losing over 50 pounds and Christopher shedding more than 100 pounds. The episode covers their personal experiences, weekly weigh-ins, dosing challenges, lifestyle changes, and answers to viewers' questions about these medications. They emphasize the importance of consulting a doctor for personalized advice and share their strategies for long-term weight maintenance. The show also highlights their upcoming meetups and sponsored products like Lenza supplements designed for GLP-1 users. They provide valuable insights into navigating the food and weight loss journey while balancing their health. The episode underscores the unpredictability of weight loss with GLP-1 medications, noting that individual experiences may vary. They encourage patience and consistency, reminding viewers that weight loss is not a sprint but a marathon. Key topics include fat absorption issues post-liposuction, maintaining a calorie deficit, and the pros and cons of different GLP-1 medications. For those considering starting their own GLP-1 journey, they offer a thorough overview of medication options and encourage collaboration with healthcare providers for the best results. Replenza's free lifestyle guide: https://www.replenzalabs.com/pages/lifestyle-guide 33% off Replenza bundle: https://www.replenzalabs.com/products/replenza-bundle DOWNSIZED GLP-1 COMPANION PRODUCT STORE: https://thedownsized.org/downsized-store/ DOWNSIZED WEBSITE: https://thedownsized.org/ BOOK THE DOWNSIZED AT SEA CRUISE 2026: https://thedownsized.org/downsized-at-sea-2026/ JOIN CLUB DOWNSIZED: https://www.youtube.com/@thedownsized/join 00:00 Diet, Dose or Drug? Solving the GLP-1 Weight Loss Mystery 01:23 Our GLP-1 Journey 01:48 Laraine's Weight Loss Story 05:17 Sponsored Segment: Lenza Supplements 06:19 Christopher's Weight Loss Update 13:42 Meetups and Events 15:16 Viewer Questions and Answers 19:33 Discussing Tirzepatide and Weight Loss Medications 19:49 Diet and Meal Planning Tips 21:52 Calorie Counting and Awareness 22:42 GLP-1 Injections and Liposuction Concerns 24:23 Understanding Medication Inconsistencies 27:10 Approaching Weight Loss as a Marathon 28:03 Entering Maintenance Phase 33:34 Exploring GLP-1 Medication Options 36:03 Purchasing Syringes and Compounded Medications 39:35 Conclusion and Farewell