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View show notes here: https://bit.ly/3GJjQKz Become a member to receive exclusive content: https://peterattiamd.com/subscribe/ Sign up to receive Peter's email newsletter: https://peterattiamd.com/newsletter/ Colleen Cutcliffe is an expert in molecular biology and co-founder of Pendulum Therapeutics, a company working to develop treatments for a variety of diseases by targeting the microbiome. In this episode, Colleen delves into the complexity of the microbiome, how it is tested, and how it changes over time. She explores how probiotics, prebiotics, and postbiotics affect the gut and makes a compelling case that well-developed products have the potential not only to enhance gut health but also to positively influence overall metabolic well-being. Colleen emphasizes the significance of a high-fiber diet in sustaining a thriving gut microbiome, shares insights on minimizing microbiome damage during antibiotic use, provides tips for fostering and preserving a healthy gut, and much more. We discuss: 0:00:00 - Intro 0:00:34 - Colleen’s background and current focus 0:03:08 - The basics of the microbiome 0:12:37 - The study of the human microbiome 0:17:42 - Categories of bacteria, and the implications on health of the rapid evolution of bacteria 0:27:51 - Methods for measuring and understanding the microbiome, and key indicators of microbiome health 0:39:52 - The important role of fiber for promoting gut health through the production of butyrate 0:47:21 - The case for manipulating gut bacteria via fecal microbiota transplant (FMT) 0:53:25 - Dynamics of the microbiome: the gut-brain connection and how antibiotics, nutrition, stress, and more impact the microbiome's diversity and function 0:59:16 - Factors that influence the vaginal microbiom 1:03:46 - The effect of gut microbes on obesity and challenges with fecal transplants in people 1:06:25 - Beneficial strains of gut bacteria and strains commonly found in probiotics 1:16:35 - The difference between a probiotic and prebiotic, and how CFUs are a measure of the “active ingredient” 1:21:47 - Considerations about how probiotic strains are produced, and more on the meaning of CFU 1:31:12 - Mitigating the effect of antibiotics on the microbiome 1:39:58 - What do we know about the effect of artificial sweeteners on the gut microbiome? 1:47:02 - Why Akkermansia is a keystone strain with implications for metabolic health and an individual’s response to dietary interventions 1:58:14 - The essential steps necessary to develop a robust probiotic for optimal health support 2:01:45 - How Akkermansia helps control blood glucose, and potential implications of Akkermansia in weight loss, diabetes management, and more 2:22:46 - Pendulum Therapeutics’ commitment to rigorous product develop 2:29:54 - Details about the probiotic “Glucose Control” and other probiotics developed by Pendulum Therapeutics 2:38:43 - Further studies of Akkermansia that have been proposed or are underway -------- About: The Peter Attia Drive is a deep-dive podcast focusing on maximizing longevity, and all that goes into that from physical to cognitive to emotional health. With over 70 million episodes downloaded, it features topics including exercise, nutritional biochemistry, cardiovascular disease, Alzheimer’s disease, cancer, mental health, and much more. Peter Attia is the founder of Early Medical, a medical practice that applies the principles of Medicine 3.0 to patients with the goal of lengthening their lifespan and simultaneously improving their healthspan. Learn more: https://peterattiamd.com Connect with Peter on: Facebook: http://bit.ly/PeterAttiaMDFB Twitter: http://bit.ly/PeterAttiaMDTW Instagram: http://bit.ly/PeterAttiaMDIG Subscribe to The Drive: Apple Podcast: http://bit.ly/TheDriveApplePodcasts Overcast: http://bit.ly/TheDriveOvercast Spotify: http://bit.ly/TheDriveSpotify Google Podcasts: http://bit.ly/TheDriveGoogle Disclaimer: This podcast is for general informational purposes only and does not constitute the practice of medicine, nursing, or other professional healthcare services, including the giving of medical advice. No doctor-patient relationship is formed. The use of this information and the materials linked to this podcast is at the user's own risk. The content on this podcast is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Users should not disregard or delay in obtaining medical advice for any medical condition they have, and they should seek the assistance of their healthcare professionals for any such conditions. I take conflicts of interest very seriously. For all of my disclosures and the companies I invest in or advise, please visit my website where I keep an up-to-date and active list of such companies. For a full list of our registered and unregistered trademarks, trade names, and service marks, please review our Terms of Use: https://peterattiamd.com/terms-of-use/

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Source: https://www.podbean.com/eau/pb-rhvpn-17e8204 Welcome back to another lively episode of the Life Happens, Laugh Anyway podcast with comedian Tracy DeGraaf and co-host Cathrine. In this episode, the duo dives into the hot-topic drug, Ozempic, exploring its history, intended uses, and the buzz it's created in the weight loss community. Listeners will enjoy Tracy and Cathrine's humorous take on Ozempic's catchy commercial tune, while gaining insight into the pros and cons of using such medication for weight loss. From their personal weight struggles to their views on the role of lifestyle changes, the discussion spans the serious to the comical. Tune in to hear about real-life horror stories, explore alternatives to weight loss medications, and get inspired by the ladies' call to action—embracing health and humor as essential companions in life's journey. Don't miss their heartfelt exchange and playful banter that underline the importance of supporting each other through the challenges of maintaining a healthy lifestyle. A note from your hosts...   We are inching our way to adding video to our podcast!  Yes, it's true. It is taking us forever (mainly because we don't know tech and we don't have the funds to buy fancy equipment and hire someone to do it for us....ha ha. But, we are getting there. Your contribution (no matter the size) helps us tremendously and brings smiles to our faces. ;0)   So, if you LOVE the podcast...if you look forward to Wednesdays because you are pretty sure there will be a new episode...   Become a Humor Contributor by donating $5 per month or a one-time gift of any amount. Click here to go to Tracy's website and help us offset the cost of producing weekly episodes for your binging pleasure and personal growth.   Funds collected from our Humor Contributors are used for: monthly platform fees email service fees editing costs equipment upgrades And...we are adding video to this podcast ASAP! If you look forward to each episode, please help us keep going and growing by crossing over from Humor Consumer to Humor Contributor.    Thank you so much! Tracy and Cathrine

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