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Los agonistas del receptor de GLP-1 (péptido similar al glucagón tipo 1) son una clase de medicamentos utilizados principalmente para tratar la diabetes tipo 2 y, en algunos casos, la obesidad. Estos medicamentos imitan la acción de la hormona natural GLP-1, que se produce en el intestino después de comer y desempeña un papel clave en la regulación de los niveles de glucosa en sangre. Mecanismo de acción: Los agonistas de GLP-1 actúan de varias maneras: Estimulación de la secreción de insulina: Aumentan la liberación de insulina desde el páncreas en respuesta a la glucosa elevada en sangre, lo que ayuda a reducir los niveles de glucosa. Inhibición de la secreción de glucagón: Reducen la liberación de glucagón, una hormona que aumenta los niveles de glucosa en sangre. Retraso del vaciamiento gástrico: Esto reduce la velocidad a la que la glucosa entra en la sangre después de comer, lo que ayuda a controlar los picos de glucosa. Reducción del apetito: Muchos agonistas de GLP-1 también tienen un efecto anorexígeno, lo que puede ayudar a perder peso. Efectividad: La efectividad de los agonistas de GLP-1 se ha demostrado en varios ensayos clínicos: Control glucémico: Estos medicamentos son eficaces para reducir los niveles de hemoglobina glucosilada (HbA1c), un indicador clave del control glucémico a largo plazo. Pérdida de peso: Además de mejorar el control glucémico, muchos agonistas de GLP-1 promueven la pérdida de peso, lo cual es beneficioso para personas con diabetes tipo 2 y obesidad. Reducción del riesgo cardiovascular: Algunos agonistas de GLP-1 han mostrado beneficios cardiovasculares, como la reducción del riesgo de eventos cardiovasculares mayores (como ataques cardíacos y accidentes cerebrovasculares) en personas con diabetes tipo 2 y enfermedad cardiovascular establecida.

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