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With millions of people now taking GLP-1 agonists like Ozempic and Wegovy, I was curious to learn if there are known genetic mutations that predispose people to have serious side effects from these medications. So exploring the pharmacogenomic aspects of Ozempic and Wegovy. To answer these questions Dr. Josiah Allen is joining the show. Josiah Allen, PharmD, has spent over 15 years in the field of pharmacogenomics, beginning at the Mayo Clinic where he helped develop the GeneSight test. As a founding employee and the first medical science liaison at Assurex Health, he helped GeneSight become one of the fastest growing molecular diagnostic tests in history. He later served as director of medical affairs at OneOme and now works at St. Elizabeth Healthcare in Edgewood, KY, as a precision medicine pharmacist and PGY2 Clinical Pharmacogenomics pharmacy residency program director. He earned his bachelor's degree in psychology from Wheaton College and his Doctor of Pharmacy degree from the University of Minnesota. Topics Covered: The basics of pharmacogenomics and its role in personalized medicine. How genetic mutations, like those in the RET gene, influence medication risks. The pharmacogenomics of GLP-1 agonists (like Ozempic and Wegovy), including their contraindications for patients with RET mutations. Insights into the overlap between ACMG secondary findings and pharmacogenomic implications. Case studies illustrating the real-world impact of pharmacogenomics. Key Takeaways: GLP-1 agonists, such as Ozempic and Wegovy, carry a black box warning due to an association with thyroid cancer, particularly in individuals with RET gene mutations. Over one-third of the ACMG secondary findings genes have pharmacogenomic implications, emphasizing the need for clinicians to integrate genetic insights into prescribing practices. Pharmacists and geneticists need closer collaboration to bridge the gap between clinical genomics and pharmacogenomics for safer medication use. Get ready, genetic nerds—another brand-new episode of DNA Today drops next Friday! You can always count on us to deliver fresh content every Friday. While you wait, why not dive into our library of over 300 episodes? Binge them all on Apple Podcasts, Spotify, our website, or wherever you love to listen—just search “DNA Today.” DNA Today is hosted and produced by Kira Dineen, MS, LCGC, CG(ASCP)CM . Our Video Lead is Amanda Andreoli. Our Social Media Lead is Kajal Patel. Our Outreach Intern is Liv Davidson. And our logo Graphic Designer is Ashlyn Enokian, MS, CGC. See what else we are up to on Instagram, X (Twitter), BluSky, Threads, LinkedIn, Facebook, YouTube all at DNATodayPodcast. Our website is DNAToday.com. Questions/inquiries can be sent to [email protected].

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How to Grill Salmon on the Pit Boss | Zepbound & GLP-1 Friendly Recipe 💥 Grab the same Pit Boss Grill I use here: https://amzn.to/3I1yVv4 In this video, I’m showing you exactly how I grill salmon on the Pit Boss Pellet Grill — simple, juicy, and packed with flavor. If you're on Zepbound, Ozempic, Wegovy, or any other GLP-1 weight loss journey, this is the perfect high-protein, low-carb meal to help you stay full and on track. 🔥 Want the same Pit Boss Grill I’m using? Check it out here: ✔️ Pit Boss Pellet Grill on Amazon ✔️ Best Pit Boss Grill for BBQ Lovers ✔️ Pit Boss Smoker & Grill Combo Why this recipe works: ✅ High-protein, low-carb meal ✅ Great for Zepbound, Ozempic, or GLP-1 users ✅ Simple, flavorful, and satisfying ✅ Helps you stay on track with your weight loss journey If you're trying to lose weight, improve your meals, or just love grilled salmon, make sure to like, comment, and subscribe! Let me know your favorite way to grill salmon down below. Disclaimer: I’m not a doctor — just sharing my experience on Zepbound, working to lose weight, eat better, and keep it real. Some links in this description are Amazon affiliate links. If you purchase through them, I might earn a small commission — no extra cost to you. Thanks for supporting the channel! #PitBossGrill #GrilledSalmon #ZepboundRecipes #GLP1Friendly #WeightLossMeals #HealthyGrilling #BBQLife #ZepboundAndMe #HighProteinMeal

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Mounjaro Week 32 Update | The Worst Side Effect Yet… This week has been one of the toughest yet on my Mounjaro journey—diarrhoea, diarrhoea, and more diarrhoea! I couldn’t stay off the toilet all week, which led to major dehydration and rapid weight loss… only to regain it all once I rehydrated. In this video, I’ll be sharing my experience, how I managed my symptoms, and what this means for my weight loss going forward. Have you experienced anything like this on Mounjaro? Let me know in the comments! Don’t forget to like, comment, and subscribe for more updates on my weight loss journey! 📲 Follow me for daily updates: TikTok & Instagram: @shane90dayfiance 📩 Business inquiries: [email protected] #Mounjaro #WeightLossJourney #MounjaroSideEffects #Ozempic #GLP1 #WeightLoss Let me know if you’d like any changes! For those looking to begin their medical weight loss journey or switch providers, don't forget you can use my code SHANE10 at checkout on www.rightangled.com for 10% off any weight loss medication. This discount is reusable every month for reorders too! Thanks for watching and supporting us-see you next week! As always, my intro and outro were created using my Canva Pro account, and I have the rights to use all audio in my clips under YouTube and Canva’s Fair Use policies. Song used is Future Electronic (Upbeat Music) Content owners are - Nver Avetyan - Royaltyfreemusic

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James Keys and Tunde Ogunlana consider whether American society needs GLP-1 drugs because of the way they work on people’s brains to help them eat less, particularly because the food industry in America apparently has gotten so good at formulating foods that work on people’s brains to make them addictive so people eat more. The guys also consider why so many people feel the need to hide their use of the drugs in light of how popular they are. https://www.nytimes.com/2025/05/07/opinion/ozempic-weight-loss-drugs.html https://www.theguardian.com/lifeandstyle/2025/may/11/weight-loss-drugs-why-do-people-lie-about-taking-ozempic

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