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Investigation on the Effects of GLP1 analog and SGLT2 inhibitor against Diabetic Cardiomyopathy in Type 2 Diabetic Rats: Possible Underlying Mechanisms Background: The present study investigated the possible cardioprotective effects of GLP1 and SGLT2i against diabetic cardiomyopathy (DCM) in type 2 diabetic rats and the possible underlying mechanisms. DCM is defined as the presence of heart failure in absence of coronary artery disease. Methods: Thirty-two male Sprague Dawley rats were randomly subdivided into 4 equal groups; a) control group, b) DM group, type 2 diabetic rats with saline daily for 4 weeks, c) DM+ GLP1, as DM group with GLP1 analogue (liraglutide) at a dose of 75 µg/kg for 4 weeks, and d) DM+ SGLT2i: as DM group with SGLT2 inhibitor (dapagliflozin) at a dose of 1mg/kg for 4 weeks. By the end of treatment (4 weeks), serum blood glucose, HOMA-IR, insulin and cardiac enzymes (LDH, CK-MB) were measured. Also, the cardiac histopathology, myocardial oxidative stress markers (MDA, GSH and CAT) and norepinephrine (NE), myocardial fibrosis, the expression of caspase-3, TGF-, TNF- and tyrosine hydroxylase (TH) in myocardial tissues were measured. Results: T2DM caused significant increase in serum glucose, HOMA-IR, serum CK-MB and LDH (p less than 0.05). Also, DM caused significant myocardial damage and fibrosis, elevation of myocardial MDA, NE with upregulation of myocardial caspase-3, TNF-, TGF- and TH and significant decrease in serum insulin and myocardial GSH and CAT (p less than 0.05). Administration of either GLP1 analog and SGLT2i caused in significant improvement in all studied parameters (p less than 0.05). Conclusion: We concluded that either of GLP1 and SGLT2i exhibited cardioprotective effects against DCM in T2DM with the upper hand for SGLT2i. This might be due to attenuation of fibrosis, oxidative stress, apoptosis (caspase-3), sympathetic nerve activity and inflammatory cytokines (TNF- and TGF-). #type #2 #cardiomyopathy #oxidative #stress #3 #glp1 #norepinephrine #tgf #tnf #and #tyrosine

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Watch the full interview we held on 22 July with Dr Bart van der Schueren, EMA expert, endocrinologist and obesity specialist, to explore GLP-1 receptor agonists. GLP-1s are prescription medicines, indicated for the treatment of type 2 diabetes and for weight management in people living with obesity or overweight with weight-related health conditions. Public interest around them, mostly around their use for weight-loss, has grown considerably in the last years. From academic and medical discussions to social media, from gossip to celebrity endorsements, GLP-1s are everywhere. In this video we dive into: - what these medicines are, - how they are used, - who they can really help, - why they are not an easy weightloss solution. Do you want more information on GLP-1 medicines ? Watch the recording and find out more: https://www.ema.europa.eu/en/news/eu-actions-tackle-shortages-glp-1-receptor-agonists

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Traveling for the holiday season? Dr. Mike Bohl, director of medical content & authority at Hims, shares tips for traveling with GLP-1 medications. If you're wondering, can I travel on an airplane with syringe needles? Or, how can I keep my medication cool when traveling? Dr. Bohl answers these questions and more. Visit our blog to learn more. Weight Loss Medications: Are They Effective? https://www.hims.com/blog/weight-loss-medication Subscribe to Hims on YouTube: https://www.youtube.com/@forhims?sub_confirmation=1 Hims can help with weight loss. Start your free visit here: https://www.hims.com/weight-loss Why Hims? ✅ Free medical consultation ✅ Discreet shipping, if prescribed ✅ 100% online process ✅ Trusted generic alternatives to the biggest brands Prescription products require an online consultation with a medical professional who will determine if a prescription is appropriate. Restrictions apply. See website for full details and important safety information. https://www.hims.com/ The information provided here is NOT MEDICAL ADVICE and is for informational purposes only. Please contact your provider if you have any further questions regarding your condition or treatment. Follow Hims on social: Facebook: https://www.facebook.com/wearehims Twitter: https://twitter.com/wearehims Instagram: https://www.instagram.com/hims/ TikTok: https://www.tiktok.com/@hims

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