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Hey guys, I'm back with another video! This time, we will cover the basics of cannabinoids. We'll discuss the history, biochemistry, pharmacology and total synthesis of these highly useful natural products. Recent research is used as an example of the importance and potential of cannabinoids in medicine. https://www.instagram.com/totalsynthesis_official/ https://www.patreon.com/totalsynthesis https://www.total-synthesis.com This video does not endorse the preparation of illegal substances. No detailed steps or procedures for syntheses of illegal drugs are discussed. I hope it's clear that here we focus on fascinating aspects of science and on the potential that compounds have in improving the lives of patients. 00:00 Introduction of medical cannabinoids; Applications of cannabidiol (CBD) and tetrahydrocannabinol (THC) for treatment of epilepsy and other conditions; Introduction of legal high of liverwort 04:35 History and Isolation of THC; Discovery of the endocannabinoid system, endocannabinoid receptors (CB1 and CB2) and endocannabinoids anandamide and arachidonylglyceride; CB1 antagonists as anti-obesity drugs; Total synthesis of THC and CBD by Raphael Mechoulam at the Weizmann Institute 15:18 Can you get legally high from moss or liverwort? Summary of pharmacological results from the key paper, based on work of Professor Gertsch and co-workers at the University of Bern; Tetrad test, Prostaglandins; Implications for medicinal applications 21:32 Organic synthesis and two total syntheses of cis-perrottetine by Professor Carreira at ETH Zürich (2018) and Professor Kim at Seoul University (2008); Discussion of key steps and synthetic strategies and reaction mechanisms 28:17 Closing remarks Mechoulam interview/documentary: - The Scientist (2015): https://www.youtube.com/watch?v=fu6FhJIyTEc Liverwort paper: - Uncovering the psychoactivity of a cannabinoid from liverworts associated with a legal high (Science Advances 2018, 4, 2166): http://advances.sciencemag.org/content/4/10/eaat2166 Some recommended books on organic synthesis: - Clayden, Greeves, Warren; Organic Chemistry (basic organic chemistry knowledge) - Wyatt, Warren; Organic Synthesis: The Disconnection Approach (excellent introduction to retrosynthesis) - Kurti, Czako; Strategic Applications of Named Reactions in Organic Synthesis (extensive toolkit of reactions and applications thereof with common conditions) - Nicolaou et al; Classics in Total Synthesis 1-3 (the ultimate total synthesis trilogy) - Nicolaou; Molecules That Changed the World (the world's most important molecules and their impact on everyday life) - Carreira, Kvaerno; Classics in Stereoselective Synthesis (compilation of the groundbreaking methods of stereoselective synthesis and application to synthesis of stereochemically complex structures)

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As the popularity of hemp and CBD products continues to rise, there is often confusion surrounding the differences between hemp oil and CBD oil. While both are derived from the same plant, they have distinct properties and uses that set them apart. Understanding these differences is crucial for consumers looking to make informed decisions about their wellness routine.

The Origins of Hemp Oil and CBD Oil

Hemp oil is extracted from the seeds of the hemp plant, which contain little to no CBD or THC. It is often used in cooking and skincare products for its nutritious properties, such as high levels of omega-3 and omega-6 fatty acids. On the other hand, CBD oil is derived from the flowers, leaves, and stalks of the hemp plant, containing high levels of CBD and minimal levels of THC. CBD is known for its potential therapeutic benefits, including pain relief, anxiety reduction, and improved sleep.

When it comes to their uses, hemp oil is primarily used in culinary applications, skincare products, and as a dietary supplement due to its nutritional content. It is a versatile ingredient that can be incorporated into a variety of recipes, from salad dressings to smoothies. On the other hand, CBD oil is commonly used for its potential health benefits, with many people turning to it for relief from chronic pain, inflammation, anxiety, and insomnia.

The Extraction Process

The extraction process for hemp oil involves cold-pressing the seeds to extract the oil, preserving its nutritional benefits. This method does not involve the use of solvents or heat, ensuring that the oil retains its natural properties. On the other hand, CBD oil is typically extracted using a CO2 extraction method, which involves using carbon dioxide under high pressure and low temperatures to isolate and preserve the CBD content. This process is more complex and requires specialized equipment, resulting in a higher concentration of CBD in the final product.

Another key difference between hemp oil and CBD oil is their cannabinoid content. Hemp oil contains trace amounts of cannabinoids, including CBD and THC, but in much lower concentrations than CBD oil. CBD oil, on the other hand, contains high levels of CBD and minimal to no THC, making it non-psychoactive and legal in many places.

Legal Considerations

While hemp-derived CBD products are legal in many states, the legality of CBD oil can vary depending on the source of the extract. CBD oil derived from hemp containing less than 0.3% THC is federally legal under the 2018 Farm Bill, but CBD oil derived from marijuana is subject to different regulations. It is important for consumers to research the laws in their state regarding CBD products to ensure compliance.

In conclusion, hemp oil and CBD oil are two distinct products with different properties and uses. Hemp oil is primarily used in cooking and skincare products, while CBD oil is known for its potential health benefits. Understanding the differences between the two can help consumers make informed choices about which product is right for them.

Summary and FAQ

Overall, hemp oil and CBD oil have unique properties and uses that differentiate them from each other. Hemp oil is rich in nutrients and is commonly used in culinary and skincare products, while CBD oil is valued for its potential therapeutic benefits. It is essential for consumers to be aware of these differences when considering which product to incorporate into their wellness routine.

1. Can hemp oil get you high?

No, hemp oil does not contain significant amounts of THC, the psychoactive compound found in cannabis.

2. Is CBD oil legal?

CBD oil derived from hemp containing less than 0.3% THC is federally legal under the 2018 Farm Bill, but regulations may vary by state.

3. What are the potential benefits of CBD oil?

CBD oil is known for its potential therapeutic effects, including pain relief, anxiety reduction, and improved sleep quality.

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