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In this conversation, Emma Davis shares her journey of creating a CBD product for animals, driven by personal experiences with pain management and a desire to help pets. She discusses the challenges of dosing and manufacturing, the complexities of marketing in a restricted industry, and her future goals for brand expansion. Emma also explains the science behind CBD and its effects on animal health, emphasizing the importance of the endocannabinoid system in managing pain and anxiety in pets. Takeaways • Emma's journey began after a serious injury and personal experience with CBD. • Her dog’s cancer remission inspired her to create CBD products for pets. • Dosing for animals is complex and varies by individual. • Marketing CBD products is challenging due to legal restrictions. • SEO and content marketing are key strategies for her business. • Hemp products are legal to sell and ship across the U.S. • Emma aims to be a leading brand in CBD for animals. • She is exploring niche markets, including products for pigs. • The potency of her products sets them apart from competitors. • Understanding the endocannabinoid system is crucial for CBD efficacy. Today's guest, Emma Davis, can be found online at: Website: https://mikkoschoice.com/ Facebook: https://www.facebook.com/Mikkoschoice LinkedIn: https://www.linkedin.com/in/emma-brayfield-02a8b1b6 Your host, Scott Turman, can be found online at: BrightRay Publishing: https://brightray.com/ Entrepreneur Website: https://scottturman.com/ LinkedIn: https://www.linkedin.com/in/scottturman/ Keywords CBD, animals, pet health, dosing, manufacturing, marketing, hemp, cannabis, endocannabinoid system, animal wellness
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Scientists have shown that an active ingredient of cannabis significantly upregulates autophagy, extending both lifespan and healthspan in C. elegans nematode worms and demonstrating benefits to mouse neurons. Two of the most well-known components of marijuana are tetrahydrocannabinol, or THC, and cannabidiol, or CBD. They have the same atomic composition, but differ in structure. THC provides the high that is often associated with marijuana use. CBD, on the other hand, is considered benign and seems to possess antipsychotic, pro-cognitive, anti-inflammatory, anti-seizure, and antioxidant properties. In June 2018, the FDA approved Epidiolex, the first CBD-based prescription medication, for rare forms of epilepsy, and later for the treatment of some seizures. However, the research into both compounds is still in its infancy. In this new study, scientists dived deeper into the workings of CBD using C. elegans nematode worms, which is considered a good model for initial studies, including in geroscience. Previous research has shown that CBD can increase lifespan in C. elegans and zebrafish, but the mechanism had remained unknown. Another study found that CBD induces autophagy in cultured neuronal cells. In this new study, the researchers attempted to investigate the relationship between these two effects. Autophagy is the process of clearing away various cellular debris, such as misfolded proteins and dysfunctional organelles. Unsurprisingly, this maintenance system appears to be very important for health and longevity in numerous model organisms and in humans. The CBD treatment greatly increased autophagic activity in several tissues and cell types, most drastically by 78% in neurons. The researchers then validated those findings in vitro on several types of cells, including mouse primary hippocampal neurons. Importantly, impaired autophagy in the brain is considered a major cause of Alzheimer’s disease. Worms on CBD lived significantly longer than controls. The researchers also measured the worms’ healthspan. Many interventions that prolong lifespan in C. elegans often lead to functional impairment, such as decreased motility. Three popular health metrics in C. elegans that decline with age are pharyngeal pumping rate, reproductive capacity, and locomotion, and all three were significantly restored, rather than impaired, by CBD treatment. The gene SIRT1 has been a popular object of study in geroscience. One of its roles is a mediator of autophagy. By knocking out SIRT1 in mouse neurons, researchers were able to obliterate many of the benefits of CBD, pointing at a crucial role of SIRT1 in mediating CBD-induced effects. This study expands our understanding of CBD's effects, linking them to autophagy, an important process that keeps popping up on geroscientists' radars. It is encouraging that CBD demonstrates the strongest pro-autophagy effect in neurons, making it a potential anti-Alzheimer’s drug. Obviously, the fact that CBD increases autophagy in worms does not mean that using marijuana makes humans healthier, and we’ll need to see human trials on CBD and other compounds. SOURCES AND FURTHER READING ⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺ Cannabidiol induces autophagy and improves neuronal health associated with SIRT1 mediated longevity - https://pubmed.ncbi.nlm.nih.gov/35445360/ Effect of Cannabidiol on the Long-Term Toxicity and Lifespan in the Preclinical Model Caenorhabditis elegans - https://pubmed.ncbi.nlm.nih.gov/33998871/ Developmental exposure to cannabidiol (CBD) alters longevity and health span of zebrafish (Danio rerio) - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7205952/ Cannabidiol induces autophagy via ERK1/2 activation in neural cells - https://www.nature.com/articles/s41598-021-84879-2 EPIDIOLEX - https://youtu.be/zepKBzlKzdY FOOTAGE, IMAGES, AND MUSIC CREDITS ⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺ Stock footage & Images : Videoblocks.com, Shutterstock.com Music: "Elastic Vibe" by Ziv Moran PRODUCTION CREDITS ⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺ Host, Producer, & Editor - Ryan O’Shea Writer - Arkadi Mazin Art - Mattijs Vonk, Tim Maupin Executive Producer - Keith Comito #CBD #Science #Longevity
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Our goal is to help patients live better and happier by optimizing their performance levels. Follow us on our socials: Instagram: https://www.instagram.com/myfitmed/?hl=en Tiktok: https://www.tiktok.com/@myfitmed Twitter:https://mobile.twitter.com/myfitmed Facebook:https://www.facebook.com/MyFitMed/ Book your appointment now! https://www.myfitmed.com/schedule For any questions, call us at 469.320.1409. Like & Subscribe Sub to our channel: https://www.youtube.com/channel/UClbeyeKuWQrdwKWBC_qyZeg DISCLAIMER: This video is purely educational and does not constitute medical advice. The content of this video is my personal opinion and not that of my employer(s). Use of this information is at your own risk. Please talk to your medical provider prior to starting any treatment. Jwalant Patel, PA-C will not assume any liability for any direct or indirect losses or damages that may result from the use of the information contained in this video including but not limited to economic loss, injury, illness, or death. #myfitmed
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Dr. Jagmeet Sethi, MD, discusses the difference between CBD and CBG in medical cannabis. Benefits for each cannabinoid are discussed. Continuation of series on Compare Cannabinoids in medical cannabis.
YouTube Channel: @sethicannabisclinic
Dr. Jagmeet Sethi MD, FRCPC
Internal Medicine Specialist
Sethi Cannabis Clinic, Ontario, Canada
Website: sclinic.ca
#cbg #cbd #cbdvscbd #comparecannabinoids #cannabinoids #cannabigerol #cannabinoids #cannabidiol #drjagmeetsethi #sethicannabisclinic #health #cannabiseducation #medicalcannabispatient #medicalcannabispatient
Medical Cannabis Videos by Dr. Jagmeet Sethi videos/podcast is a series of educational videos/podcasts. These videos/podcasts are for general information purposes only. They are not meant to diagnose and treat medical conditions and do not substitute care provided by your doctor or other health care professionals. These videos/podcasts by Dr. Jagmeet Sethi are not meant for a doctor-patient relationship. No doctor-patient relationship is formed. Please see your doctor for any medical conditions. Using this information and links from these videos is at the user's own risk. Cannabis use is recommended in people aged 25 years or older. If this is a medical emergency, please seek your doctor or nearest emergency room or call emergency services at 911.
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