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In 2018, the FDA granted approval to cannabidiol (CBD; Epidiolex) for the treatment of rare forms of epilepsy, Dravet syndrome and Lennox-Gastaut syndrome, and while the addition was a welcomed one, this did not mark the complete understanding of the therapy’s use. Although CBD and other medications continue to be studied in some instances post-approval and often for other conditions, the need for subgroup analyses—especially in epilepsy—is paramount. As Kelly Knupp, MD, pediatric neurologist and epilepsy specialist, Children’s Hospital Colorado, pointed out in a conversation with NeurologyLive, when it comes to CBD, physicians still do not completely understand why specific subgroups of patients respond to CBD and others do not. “I think it would be worthwhile to look at that and try to figure that out,” Knupp said. The data from the clinical trials are compelling, she noted, but it’s important to remember that patients, while achieving reductions, have not been achieving seizure freedom. At the 2019 International Epilepsy Congress, June 22-26, in Bangkok, Thailand, she spoke about the use of cannabinoids in epilepsy and where they may play a role in other epilepsies.

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Dr. Dustin Sulak and Bonni Goldstein MD present current research and answer live questions on various topics. This is a recording of the live webinar with took place on November 17, 2021. Research Topics: •CBG – a review of mechanisms of action •CBG in a mouse model of PTSD •CBGA in a mouse model of epilepsy •CBG and brain cancer cells •CBG and breast cancer cells •Anti-inflammatory effects of CBG and CBD, alone and in combination •CBG and CBD in Parkinson’s and Lewy Body Dementia – a case series •Q&A

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What percentage of patients experience therapeutic benefits from cannabinoid medicine? Does this vary based on the diagnosis? In this Q&A, I discuss how outcomes differ depending on the condition being treated and why an individualized approach is key in cannabinoid-based therapies. Let’s advance the conversation around cannabinoid medicine together—follow for more clinical insights and case discussions. #CannabinoidMedicine #MedicalCannabis #HealthcareProfessionals

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