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Carlat Psychiatry News | Stimulant Fraud • Oral Ketamine • E-Cigarettes • Benzo Tapering • CBD 💡Subscribe to our newsletter: https://www.thecarlatreport.com/products ➡️Check out our website: https://www.thecarlatreport.com/ ================ Follow Carlat: 🔴SUBSCRIBE ► / @thecarlatreport ➡️Twitter: / CarlatPsych ================ References: Hines, Lindsey A et al. “Incident psychotic experiences following self-reported use of high- potency cannabis: Results from a longitudinal cohort study.” Addiction (Abingdon, England) vol. 119,9 (2024): 1629-1634. doi:10.1111/add.16517 Fucito, Lisa M et al. “Varenicline for E-Cigarette Cessation in Adults: A Preliminary Placebo- Controlled Randomized Trial.” American journal of preventive medicine vol. 67,2 (2024): 296- 298. doi:10.1016/j.amepre.2024.04.007 Glue, Paul et al. “Extended-release ketamine tablets for treatment-resistant depression: a randomized placebo-controlled phase 2 trial.” Nature medicine vol. 30,7 (2024): 2004-2009. doi:10.1038/s41591-024-03063-x Gundugurti, Prasad Rao et al. “Evaluation of the efficacy, safety, and pharmacokinetics of nanodispersible cannabidiol oral solution (150 mg/mL) versus placebo in mild to moderate anxiety subjects: A double blind multicenter randomized clinical trial.” Asian journal of psychiatry vol. 97 (2024): 104073. doi:10.1016/j.ajp.2024.104073 Rohde, Christopher et al. “A Nationwide Target Trial Emulation Assessing the Risk of Antidepressant-Induced Mania Among Patients With Bipolar Depression.” The American journal of psychiatry vol. 181,7 (2024): 630-638. doi:10.1176/appi.ajp.20230477 Tuisku, Anna et al. “Electronic Cigarettes vs Varenicline for Smoking Cessation in Adults: A Randomized Clinical Trial.” JAMA internal medicine vol. 184,8 (2024): 915-921. doi:10.1001/jamainternmed.2024.1822 Benzodiazapene Tapering Guidelines: https://downloads.asam.org/sitefinity-production-blobs/docs/default-source/guidelines/bzd-cpg-narrative-draft-for-public-comment.pdf?sfvrsn=6d96408_2 ================ 0:00 - Intro 0:29 DOJ Charges Telehealth Executives 1:55 Oral Extended Release Ketamine 3:29 MDMA Trials Suspended 04:43 Liquid Clonidine and Liquid Lithium 5:46 Benzodiazepine Tapering Guidelines 8:01 Antidepressants in Bipolar Disorder 10:52 Vaping Trials and Smoking Cessation 12:54 Brexpiprazole & Sertraline For PTSD 14:15 CBD Oil for Anxiety #MentalHealthNews #psychiatry #psychiatricmedications #psychnews #psychiatrynews #psychopharmacology #pmhnp #psychnp ================ In this episode, we explore nine groundbreaking stories in mental health and psychiatric medicine, covering everything from healthcare fraud to the latest advancements in drug trials. Healthcare Fraud Charges: The US DOJ has charged executives at Done, a California telehealth company, for allegedly prescribing 40 million Adderall pills without proper evaluation. Extended Release Oral Ketamine: New trials on an extended release oral ketamine show potential for treatment-resistant depression. (https://pubmed.ncbi.nlm.nih.gov/38914860/) MDMA-assisted Psychotherapy Setbacks: After FDA approval was pulled due to ethical concerns, can upcoming trials revive this promising therapy for PTSD? Liquid Formulations: Onyda is brand name for the new liquid Clonidine XR and the return of liquid lithium citrate offer new options for ADHD and bipolar patients. Benzodiazepine Tapering Guidelines: The American Society of Addiction Medicine's new draft guidelinesadvocate for a careful, patient-centric approach, especially for vulnerable populations. Antidepressants and Bipolar Disorder: A Danish study provides some reassurance about using antidepressants in bipolar disorder, but its methodology leaves some questions unanswered. E-Cigarettes vs. Chantix: A new trial finds nicotine e-cigarettes as effective as Chantix for smoking cessation, but flavored vape products and their health risks continue to spark debate. Brexpiprazole and Sertraline for PTSD: Brexpiprazole showing promise as an add-on treatment to sertraline, but will the FDA approve this new therapy? CBD Oil for Anxiety: A new phase 3 trial offers hope for treating anxiety with CBD oil, though its high cost rmay emain a barrier for many patients.

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Join us as we unroll a prerolled joint from Colorado Cures and see what's truly inside. As always we hope y'all enjoyed the video and remember to spread the peace! What is REALLY in CBD Cigarettes?: https://youtu.be/dQqyEK3pyIw https://youtu.be/-wDgNCUY_sg CBD Product: Blue Genius by Colorado Cures Our socials: Insta: @weedabest_cbd Facebook: Weedabest Twitter: weedabesthereis TheWeedTube: Weedabest

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In this video, we're shedding light on the common myths surrounding cannabis side effects. As part of our cannabis awareness and education efforts, we're committed to providing accurate information to support patients who rely on medical marijuana for their health support. Join us as we explore the truth behind cannabis myths and debunk common misconceptions about cannabis therapy. With the Miracle Leaf membership, we're dedicated to providing patient care and promoting a deeper understanding of the benefits and effects of cannabis. From separating fact from fiction to exploring the latest research, we're here to empower you with knowledge and confidence. Tune in to learn more about cannabis side effects and how to make informed decisions about your health.

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Parkinson’s disease, also known as PD, is the second most common neurodegenerative disorder. The disease is characterized by a loss of dopamine-producing neurons in the substantia nigra, which is an area of the brain responsible for movement. Cannabis, specifically CBD, has shown promise in treating some of the symptoms of PD. In this video we will define Parkinson’s disease and cannabis, explain how cannabis can help with PD, and physician perspectives on prescribing cannabis. This video was created by Demystifying Medicine students Simran Matharu, Mahek Minhas and Micaela McNulty in collaboration with the McMaster Demystifying Medicine Program Copyright McMaster University 2021 For more information visit: https://www150.statcan.gc.ca/n1/pub/82-003-x/2014011/article/14112-eng.htm Time Stamps: Introduction/What is Parkinson’s Disease? → 00:00 - 01:23 What is Cannabis? → 01:24 - 02:34 How Can Cannabis Help With Parkinson’s? → 02:35 - 05:09 Physician Perspectives → 05:10 - 07:19 Conclusion → 07:20 - 07:52 References: Bega, D., Simuni, T., Okun, M. S., Chen, X., & Schmidt, P. (2016). Medicinal cannabis for Parkinson's disease: Practices, beliefs, and attitudes among providers at national Parkinson Foundation centers of excellence. Movement Disorders Clinical Practice, 4(1), 90-95. Benner, E. J., Banerjee, R., Reynolds, A. D., Sherman, S., Pisarev, V. M., Tsiperson, V., Nemachek, C., Ciborowski, P., Przedborski, S., Mosley, R. L., & Gendelman, H. E. (2008). Nitrated alpha-synuclein immunity accelerates degeneration of nigral dopaminergic neurons. PloS one, 3(1), e1376. Clapper, J. R., Mangieri, R. A., & Piomelli, D. (2009). The endocannabinoid system as a target for the treatment of cannabis dependence. Neuropharmacology, 56, 235–243. de Lau, L. M., & Breteler, M. M. (2006). Epidemiology of Parkinson’s disease. The Lancet Neurology, 5(6), 525–535. Edelstein, O. E., Wacht, O., Isralowitz, R., Reznik, A., & Bachner, Y. G. (2020). Beliefs and attitudes of graduate gerontology students about medical marijuana use for Alzheimer’s and Parkinson’s disease. Complementary Therapies in Medicine, 52, 102418. Gardiner, K. M., Singleton, J. A., Sheridan, J., Kyle, G. J., & Nissen, L. M. (2019). Health professional beliefs, knowledge, and concerns surrounding medicinal cannabis – A systematic review. PLOS ONE, 14(5), e0216556. Hauser, R. A., Rascol, O., Korczyn, A. D., Jon Stoessl, A., Watts, R. L., Poewe, W., De Deyn, P. P., & Lang, A. E. (2007). Ten-year follow-up of Parkinson's disease patients randomized to initial therapy with ropinirole or levodopa. Movement disorders: official journal of the Movement Disorder Society, 22(16), 2409–2417. Jankovic, J. (2008). Parkinson’s disease: Clinical features and diagnosis. Journal of Neurology, Neurosurgery & Psychiatry, 79(4), 368–376. Klein, C., Karanges, E., Spiro, A., Wong, A., Spencer, J., Huynh, T., Gunasekaran, N., Karl, T., Long, L. E., Huang, X.-F., Liu, K., Arnold, J. C., & McGregor, I. S. (2011). Cannabidiol potentiates Δ9-tetrahydrocannabinol (THC) behavioural effects and alters THC pharmacokinetics during acute and chronic treatment in adolescent rats. Psychopharmacology, 218(2), 443–457. Lang, A. E., & Lozano, A. M. (1998). Parkinson’s Disease. New England Journal of Medicine, 339(16), 1130–1143. Laun, A. S., & Song, Z. H. (2017). GPR3 and GPR6, novel molecular targets for cannabidiol. Biochemical and biophysical research communications, 490(1), 17–21. Marras, C., Beck, J. C., Bower, J. H., Roberts, E., Ritz, B., Ross, G. W., Abbott, R. D., Savica, R., Van Den Eeden, S. K., Willis, A. W., & Tanner, C. (2018). Prevalence of Parkinson’s disease across North America. Npj Parkinson’s Disease, 4(1), 21. Nutt J. G. (2000). Response to L-dopa in PD: the long and the short of it. Neurology, 54(10), 1884–1885. https://doi.org/10.1212/wnl.54.10.1884 Oeckl, P., Hengerer, B., & Ferger, B. (2014). G-protein coupled receptor 6 deficiency alters striatal dopamine and cAMP concentrations and reduces dyskinesia in a mouse model of Parkinson's disease. Experimental neurology, 257, 1–9. https://doi.org/10.1016/j.expneurol.2014.04.010 Severe Spasticity. (2020). https://lioresal.com/severe-spasticity/. Venderová, K., Růzicka, E., Vorísek, V., & Visnovský, P. (2004). Survey on cannabis use in Parkinson's disease: subjective improvement of motor symptoms. Movement disorders: official journal of the Movement Disorder Society, 19(9), 1102–1106. https://doi.org/10.1002/mds.20111 Wang, M., Wang, Y.-H., Avula, B., Radwan, M. M., Wanas, A. S., Mehmedic, Z., van Antwerp, J., ElSohly, M. A., & Khan, I. A. (2017). Quantitative Determination of Cannabinoids in Cannabis and Cannabis Products Using Ultra-High-Performance Supercritical Fluid Chromatography and Diode Array/Mass Spectrometric Detection. Journal of Forensic Sciences, 62(3), 602–611. https://doi.org/10.1111/1556-4029.13341