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Dr. JoAnna Harper discusses cannabis, CBD, and THC as relating to scleroderma. Q&A session has been removed due to the sensitive nature of the topic. National Scleroderma Foundation Oregon Chapter 21st Annual Cheri Woo Scleroderma Education Seminar May 14, 2022

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Marijuana is the common term for cannabis that is derived from the plant Cannabis sativa. This plan has hundreds of chemicals in it called cannabinoids. The two main cannabinoids in the cannabis plant that we’ve studies are Δ9-tetrahydrocannabinol or THC and cannabidiol or CBD. THC has mind altering properties and CBD does not. The reason cannabis has an effect in the body is that cannabinoids are neurotransmitters or chemicals that affect the activities of nerves. We make our own cannabinoids called the endocannabinoid system. The two endocannabinoids are anandamide and 2-arachidonoyl glycerol. References Castillo PE, Younts TJ, Chávez AE, Hashimotodani Y. Endocannabinoid signaling and synaptic function. Neuron. 2012;76(1):70-81. doi:10.1016/j.neuron.2012.09.020. Hillard CJ, Beatka M, Sarvaideo J. Endocannabinoid Signaling and the Hypothalamic-Pituitary-Adrenal Axis. Comprehensive Physiology. 2016;7(1):1-15. doi:10.1002/cphy.c160005. Adolescent use and lower IQ Meier MH et al, Persistent cannabis users show neuropsychological decline from childhood to midlife. Proc Natl Acad Sci USA 2012;109(40):E2657–E2664 Increased risk of psychosis in people already at risk of psychosis Nehal P. Vadhan, Cheryl M. Corcoran, Gill Bedi, John G. Keilp, Margaret Haney. Acute effects of smoked marijuana in marijuana smokers at clinical high-risk for psychosis: A preliminary study. Psychiatry Research, 2017; 257: 372 Disclaimer: All of the information on this channel is for educational purposes and not intended to be specific/personal medical advice from me to you. Watching the videos or getting answers to comments/question, does not establish a doctor-patient relationship. If you have your own doctor, perhaps these videos can help prepare you for your discussion with your doctor. I upload every Wednesday at 9am, and sometimes have extra videos in between. Subscribe to my channel so you don't miss a video https://goo.gl/DFfT33

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The official music video for Ed Sheeran - Shape Of You Subtract, the new album, out 05.05.2023. Pre-order: es.lnk.to/subtract Taken from the studio album ÷ (divide) released in 2017, which featured the hit singles 'Castle on the Hill', 'Shape of You', 'Galway Girl', ‘Perfect’ & 'Happier'. Subscribe to the Ed Sheeran channel for all the best and latest official music videos, behind the scenes and live performances.  http://bit.ly/SubscribeToEdSheeran See more official videos from Ed Sheeran here: https://www.youtube.com/watch?v=ryJgDL9jzKk&list=PLjp0AEEJ0-fGKG_3skl0e1FQlJfnx-TJz Listen to more from the album ÷ (divide): https://www.youtube.com/playlist?list=PLjp0AEEJ0-fGi7bkjrGhBLUF9NMraL9cL Follow Ed Sheeran on: Instagram: http://instagram.com/teddysphotos TikTok: https://www.tiktok.com/@edsheeran Facebook: http://www.facebook.com/EdSheeranMusic Twitter: http://twitter.com/edsheeran Discord: http://discord.gg/edsheeran Official Website: http://edsheeran.com VIDEO CREDITS: Director|DOP: Jason Koenig Producer: Honna Kimmerer Production company: Anonymous Content Exec Producer: Nina Soriano Cinematography: Johnny Valencia, Ryan Haug Edited by: Johnny Valencia, Jason Koenig Commissioner: Dan Curwin Co-Starring: Jennie Pegouskie Yama -- | LYRICS |-- The club isn’t the best place to find a lover So the bar is where I go Me and my friends at the table doing shots drinking fast and then we talk slow you come over and start up a conversation with just me and trust me I’ll give it a chance now Take my hand stop, put van the man on the jukebox and then we start to dance And now I’m singing like Girl you know I want your love Your love was handmade for somebody like me Come on now follow my lead I may be crazy don’t mind me Say boy let’s not talk too much Grab on my waist and put that body on me Come on now follow my lead Come come on now follow my lead I’m in love with the shape of you We push and pull like a magnet do Although my heart is falling too I’m in love with your body Last night you were in my room And now my bed sheets smell like you Every day discovering something brand new I’m in love with your body Oh I X 4 I’m in love with your body Oh I X 4 I’m in love with your body Oh I X 4 I’m in love with your body Every day discovering something brand new I’m in love with the shape of you One week in we let the story begin We’re going out on our first date You and me are thrifty So go all you can eat Fill up your bag and I fill up a plate We talk for hours and hours about the sweet and the sour And how your family’s doing ok leave and get in a taxi, then kiss in the backseat Tell the driver make the radio play and I'm singing like Girl you know I want your love Your love was handmade for somebody like me Come on now follow my lead I may be crazy, don’t mind me Say boy let’s not talk too much Grab on my waist and put that body on me Come on now follow my lead Come come on now follow my lead I’m in love with the shape of you We push and pull like a magnet do Although my heart is falling too I’m in love with your body Last night you were in my room And now my bed sheets smell like you Every day discovering something brand new Well I’m in love with your body Oh I x 4 I’m in love with your body Oh I x 4 I’m in love with your body Oh I X 4 I’m in love with your body Every day discovering something brand new I’m in love with the shape of you Come on be my baby come on X 8 I’m in love with the shape of you We push and pull like a magnet do Although my heart is falling too I’m in love with your body Last night you were in my room And now my bed sheets smell like you Every day discovering something brand new Well I’m in love with your body Come on be my baby come on X 6 Every day discovering something brand new I’m in love with the shape of you About Ed Sheeran: Ed Sheeran may be the quintessential pop star of the 2010s: an internationally acclaimed, multi-award winning singer/songwriter who seems to acknowledge no boundaries between styles or eras with elements of folk, hip-hop, pop, dance, soul, and rock woven throughout his music. His incredible catalogue includes the studio albums ‘+’ (plus), ‘x’ (multiply) and ‘÷’ (divide) which spawned hit singles such as ‘The A team’ , ’Lego House’, ‘Sing', ‘Thinking Out Loud’, ‘Photograph’, ‘Shape Of You’, ‘Castle on The Hill’ and ‘Perfect’. In 2019, Ed Sheeran released the genre-spanning ‘No.6 Collaborations Project’ which featured a wide-range of artists including ‘Justin Bieber’, ‘Camilla’ Cabello’, ‘Travis Scott’, ‘Eminem’, ‘Cardi B, ‘Paulo Londra’, ‘Bruno Mars’ and ‘Stormzy’ amongst many others, producing hits such as ‘I Don’t Care’, ‘Beautiful People’, ‘South of The Border’ and ‘Take Me Back To London’. #EdSheeran #ShapeOfYou #divide

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