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Dr. Naima Covassin says melatonin is not a sleep promoter. It's a circadian rhythm regulator that can help "reset our clocks" when sleep is difficult due to circadian disruption from things like shift work, jet lag or disorders that interfere with the time of sleep. Not only are more people using melatonin supplements, they're taking higher doses than the typically recommended maximum dose of 5 or fewer milligrams. Serious side effects include worsening of seizures; changes in heart rate and blood pressure; decrease in glucose tolerance; and possible drug interactions for people taking medications for seizure disorders, antidepressants and blood thinners. That's why Dr. Covassin's best recommendation is to talk with your provider. ____________________________________________ For the safety of its patients, staff and visitors, Mayo Clinic has strict masking policies in place. Anyone shown without a mask was recorded prior to COVID-19 or recorded in an area not designated for patient care, where social distancing and other safety protocols were followed. FOR THE PUBLIC: More health and medical news on the Mayo Clinic News Network. https://newsnetwork.mayoclinic.org/ FOR THE MEDIA ONLY: Register at https://newsnetwork.mayoclinic.org/re... to access clean and nat sound versions of this video on the Mayo Clinic News Network. https://newsnetwork.mayoclinic.org/ Mayo Clinic https://mayocl.in/3tNMAdF Follow Mayo Clinic on Instagram: https://www.instagram.com/mayoclinic/ Like Mayo Clinic on Facebook: https://www.facebook.com/ Follow Mayo Clinic on Twitter: https://twitter.com/MayoClinic

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For Kelly Knupp, MD, pediatric neurologist and epilepsy specialist, Children’s Hospital Colorado, the most important work with cannabidiol (CBD) still remains to be done. She told NeurologyLive that while patient interest has been increasing with the recent approval of Epidiolex (GW Pharamceuticals) for Lennox-Gastaut and Dravet syndromes, the need for data regarding its long-term safety profile and etiology-specific effects have never been higher. At the 2019 International Epilepsy Congress, June 22-26, in Bangkok, Thailand, Knupp detailed what most patients are asking about regarding CBD for their epilepsy and how it doesn’t appear to be poised to become the most highly prescribed epilepsy therapy. As for the future, she spoke to the importance of moving the field closer and closer to a precision-medicine model, and how this process is essentially necessary for all epilepsy treatment. For Knunpp, further research into the specific subgroup populations and their relationships with the treatments is still going to be the key.

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